Substituted thiophene modulators of intracellular calcium

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S118000, C546S119000, C548S152000, C548S153000, C548S217000, C549S071000, C549S471000

Reexamination Certificate

active

07906553

ABSTRACT:
Described herein are compounds of Formula (I) having the structure:where A, J, R1, R4, Z and X are described herein; and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

REFERENCES:
patent: 4658040 (1987-04-01), Baird et al.
patent: 6323227 (2001-11-01), Klein et al.
patent: 6919359 (2005-07-01), Piotrowski et al.
patent: 2004/0142980 (2004-07-01), Finzel et al.
patent: 2006/0199845 (2006-09-01), Sun et al.
patent: 2007/0249050 (2007-10-01), Chen et al.
patent: 2007/0249051 (2007-10-01), Bohnert et al.
patent: 2007/0249609 (2007-10-01), Chen et al.
patent: 2007/0249661 (2007-10-01), Chen et al.
patent: 2007/0254363 (2007-11-01), Chen et al.
patent: 2007/0254912 (2007-11-01), Chen et al.
patent: 2007/0254925 (2007-11-01), Vo et al.
patent: 2007/0254926 (2007-11-01), Jiang et al.
patent: 2009/0137659 (2009-05-01), Velicelebi et al.
patent: 2010/0305200 (2010-12-01), Velicelebi et al.
patent: WO 94/12505 (1994-06-01), None
patent: WO 98/54116 (1998-12-01), None
patent: WO 02/48131 (2002-06-01), None
patent: WO 03/13517 (2003-02-01), None
patent: WO 2005/009954 (2005-02-01), None
patent: WO 2005/033102 (2005-04-01), None
patent: WO 2006/081389 (2006-08-01), None
patent: WO 2006/081391 (2006-08-01), None
patent: WO 2006/083477 (2006-08-01), None
patent: WO 2006/089177 (2006-08-01), None
patent: WO 2006/093518 (2006-09-01), None
patent: WO 2007/017264 (2007-02-01), None
patent: WO 2007/087429 (2007-08-01), None
patent: WO 2007/112093 (2007-10-01), None
patent: WO 2008/063504 (2008-05-01), None
Jordan, V. C. Nature Reviews: Drug Discovery, 2, 2003, 205.
Vippagunta, et al. Advanced Drug Delivery Reviews, 48, 2001, 18.
Leistner, et al. Synthesis, 5, 1987, 466-470.
PCT/US2008/073392 International Search Report dated Feb. 11, 2009.
ScienceIP search report dated Feb. 19, 2007.
ScienceIP search report dated Feb. 20, 2007.
Henry, “Calcium antagonists as antiatherogenic agents”, Ann N Y Acad Sci, 522:411-9, 1988.
Schepetkin et at., “High-throughput screening for small-molecule activators of neutrophils: identification of novel N-formyl peptide receptor agonists,” Mol Pharmacol. 71(4):1061-74, 2007.
Sweeney et al., “Small-molecule inhibitors of store-operated calcium entry,” ChemMedChem. 4(5):706-18, 2009.
Yonetoku et al., “Novel potent and selective Ca2+release-activated Ca2+(CRAC) channel inhibitors. Part 3: synthesis and CRAC channel inhibitory activity of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides,” Bioorg Med Chem. 16(21):9457-66, 2008.
Yonetoku et al., “Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 1: synthesis and inhibitory activity of 5-(1-methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-2-thiophenecarboxamides,” Bioorg Med Chem. 14(14):4750-60, 2006.
Yonetoku et al., “Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 2: Synthesis and inhibitory activity of aryl-3-trifluoromethylpyrazoles,” Bioorg Med Chem. 14(15):5370-83, 2006.
PCT/US2009/055090 International Search Report dated Apr. 7, 2010.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Substituted thiophene modulators of intracellular calcium does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted thiophene modulators of intracellular calcium, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted thiophene modulators of intracellular calcium will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2644345

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.