Substituted thienyl- or pyrrolylcarboxyclic acid derivatives, th

Details Substituted thienyl- or pyrrolylcarboxyclic acid derivatives, th Substituted thienyl- or pyrrolylcarboxyclic acid derivatives, th

1993-08-19

1994-11-01

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514183, 5142328, 514255, 514292, 546 84, 544126, 544361, 540481, 540597, C07D47104, C07D41314, A61K 3144, A61K 3155

Patent

active

053607996

ABSTRACT:
Compounds of formula ##STR1## in which R.sub.1 represents OH, (C.sub.1 -C.sub.12)alkyl, (C.sub.1 -C.sub.12)alkoxy, benzyloxy, benzyl, phenyl, (C.sub.1 -C.sub.4)alkylNZ.sub.1 Z.sub.2 or NZ.sub.1 Z.sub.2 ; R.sub.2 represents OH, SH, (C.sub.1 -C.sub.4)alkoxy, (C.sub.1 -C.sub.4)alkylthio or NZ.sub.1 Z.sub.2 ; R.sub.3 represents H, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkylthio, (C.sub.1 -C.sub.4)alkoxy, phenyl or benzyl; A represents N and R represents H or (C.sub.1 -C.sub.4)alkyl which can be substituted by phenyl or NZ.sub.1 Z.sub.2 ; B represents phenyl which is coupled to the pyridyl ring and is optionally substituted by one or more groups chosen from halo, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, CF.sub.3, CH.sub.2 NZ.sub.1 Z.sub.2 or NZ.sub.1 Z.sub.2 ; and Z.sub.1 and Z.sub.2 represent, independently of each other, H, (C.sub.1 -C.sub.6) alkyl, formyl or benzyl, or they form with the nitrogen atom to which they are attached an optionally substituted saturated heterocycle and their salts.

REFERENCES:
J. M. Barker et al., "Thienopyridines. Part 4. Preparation of some dithieno(3,2-b:2i, 3i-d)pyridine derivatives", Chemical Abstracts, vol. 97, 1982, Abs. No. 144802p, p. 683.
J. M. Barker et al., "Thienopyridines. Part 6. Synthesis & nucleophilic substitution of some chlorothieno(2,3-b)pyridine . . . ", Chemical Abstracts, vol. 104, 1986, Abs. No. 5801n, p. 5797.
J. Sharada et al., "Synthesis & biological activity of furoquinolines: 2-aroyl-4-methyl/4,6-dimethyl-3-phenylfuro(3,2-c)quinolines", Chemical Abstracts, vol. 108, 1988, Abs. No. 21749q, p. 587.

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