Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-02-20
2007-02-20
Stockton, Laura L. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S303700
Reexamination Certificate
active
10926118
ABSTRACT:
Substituted thienoimidazoles with a backbone structure of formula I or II:These substituted thienoimidazoles are useful in prevention or treatment of various disorders, including respiratory disorders.
REFERENCES:
patent: 3758476 (1973-09-01), Rippel et al.
patent: 6005010 (1999-12-01), Schwark
patent: 6686384 (2004-02-01), Hofmeister
patent: 4034728 (1992-05-01), None
patent: 0483683 (1992-05-01), None
patent: WO 0121582 (2001-03-01), None
patent: WO 0172742 (2001-10-01), None
patent: WO 0179186 (2001-10-01), None
patent: WO 02/46169 (2002-06-01), None
Golub et al., Science, vol. 286, Oct. 15, 1999, pp. 531-537.
Karmazyn et al., Current Drug Targets—Cardiovascular & Hematological Disorders, vol. 5, No. 4, Aug. 2005, pp. 323-335.
U.S. Appl. No. 10/309,352, filed Dec. 4, 2002, Hofmeister.
U.S. Appl. No. 10/448,851, filed May, 30, 2003, Lang.
U.S. Appl. No. 10/770,654, filed Feb. 3, 2004, Heinelt.
U.S. Appl. No. 10/771,185, filed Feb. 3, 2004, Heinelt.
U.S. Appl. No. 10/866,843, filed Jun. 14, 2004, Hofmeister.
U.S. Appl. No. 10/892,994, filed Dec. 20, 2002, Heinelt.
U.S. Appl. No. 10/324,041, filed Dec. 20, 2002, Hofmeister.
U.S. Appl. No. 10/441,124, filed Dec. 4, 2001, Hofmeister.
U.S. Appl. No. 09/734,008, filed Dec. 12, 2000, Heinelt.
Akhter S. et al., Squalamine, A Novel Cationic Steroid, Specifically Inhibits The Brush-Border Na+/H+ Exchanger Isoform NHE3, The American Physiological Society, 276, (Cell Physiology 45), (1999) pp. C136-C144.
Ernsberger Paul et al., Clonidine Binds To Imidazole Binding Sites As Well As alpha2-Adrenoceptors In The Ventorolateral Medulla, European Journal Of Pharmacology, 134, 1, (1987) pp. 1-13.
Fliegel Larry et al., Regulation And Characterization Of The Na+/H+ Exchanger, Biochem, Cell Biology, 76, (1998), pp. 735-741.
Jen T. et al., Amidines And Related Compounds. 6. Studies On Structure-Activity Relationships Of Antihypertensive And Antisecretory Agents Related To Clonidine, Journal of Medicinal Chemistry, 18, 1, (1975), pp. 90-99.
Ma, et al., Expression And Localization Of Na+/H+ Exchangers In Rat Central Nervous System, Neuroscience, (1997), vol. 79. No. 2. pp. 591-603.
Mohsen, et al., The Cyclodesulfurization Of Thio Compounds; VII. A New Facile Synthesis Of Na-Substituted Benzimidazoles, Communication, Jan. 1974, S. 41-42.
Omar A-Moshen M.E. et al., The Cyclodesulfurization Of Thio Compounds; XVL Dicyclohexylcarbodimide As An Efficient Cyclodesulfurizing Agent In The Synthesis Of Heterocyclic Compounds From Various Thio Compounds, Synthesis, 1977, pp. 864-865.
Staab Heinz A. et al., Synthese Von Isothiocyanaten, Justus Liebigs Annalen Der Chemie, 657, (1962) pp. 104-107.
Yu, et al., Functional Properties of the Rat Na/H Exchanger NHE-2 Isoform Expressed in Na/H Exchanger-deficient Chinese Hamster Ovary Cells, J. Biol. Chem.; 268; 34; 1993; pp. 25536-25541.
Heinelt Uwe
Lang Hans-Jochen
Licher Thomas
Wirth Klaus
Gupta Balaram
Sanofi-aventis Deutschland GmbH
Stockton Laura L.
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