Substituted thiazolidinyl esters of mineral acids

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548117, C07D41712, A61K 31425

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active

045828415

ABSTRACT:
Compounds of the formula ##STR1## in which one of the symbols R.sub.1 and R.sub.2 represents an alkyl radical that has 3 or 4 carbon atoms and is unsaturated in the 2,3-position, and the other represents such a radical or lower alkyl, R.sub.3 and R.sub.4 each represents, independently of the other, hydrogen or methyl, and A represents a radical of the formula ##STR2## in which Z.sub.1, or each of Z.sub.2 and Z.sub.3 independently of the other, represents hydrogen or lower alkyl, or Z.sub.2 and Z.sub.3 together represent lower alkylene, each of R.sub.5 and R.sub.6, independently of the other, represents hydrogen, lower alkyl, halogenated lower alkyl, or lower alkenyl or R.sub.5 and R.sub.6 together represent lower alkylene that is optionally interrupted by oxygen, sulphur or by optionally substituted nitrogen, and X represents OR.sub.7 or NR.sub.8 R.sub.9 in which R.sub.7 represents hydrogen or lower alkyl and each of R.sub.8 and R.sub.9, independently of the other, represents hydrogen, lower alkyl, halogenated lower alkyl, or lower alkenyl or R.sub.8 and R.sub.9 together represent lower alkylene that is optionally interrupted by oxygen, sulphur or by optionally substituted nitrogen, or R.sub.6 together with R.sub.7 or R.sub.8 represents a lower alkylene group Alk, and salts of such compounds in which Z.sub.1, or Z.sub.3 and optionally also Z.sub.2, or R.sub.7 represent(s) hydrogen, exhibit tumor-inhibiting activities.

REFERENCES:
patent: 4489069 (1984-12-01), Storni

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