Substituted tetralone derivatives for enhancing cognition

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514278, 514336, 546 15, 5462804, 5462844, 546339, C07D21346, C07D21350, A61K 314418

Patent

active

061567612

ABSTRACT:
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein A, B, R2, R3 and q are as defined in the disclosure, pharmaceutical compositions containing them; methods for their production; their use in therapy and methods of treatment of disease states where cognition enhancement is required, such as Alzheimer's disease.

REFERENCES:
patent: 6048877 (2000-04-01), Ahmad et al.
Damasio, Alzheimer's Disease and related Dementias, Cecil Textbook of Medicine, 20th Edition, vol. 2, pp. 1992-1996, 1996.
Van Rhee, et al., J. Med. Chem., 39: 398-406 (1996).

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