Substituted tetrahydrotetrazolo[5,1-a]phthalazines

Details Substituted tetrahydrotetrazolo[5,1-a]phthalazines Substituted tetrahydrotetrazolo[5,1-a]phthalazines

1982-07-12

1984-11-27

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544234, 2602433, A61K 3150, C07D48704

Patent

active

044851065

ABSTRACT:
Substituted tetrahydrotetrazolo[5,1-a]phthalazine compounds such as 6-methylamino-7,8,9,10-tetrahydrotetrazolo[5,1-a]phthalazine are prepared by reacting a 6-halo-7,8,9,10-tetrahydrotetrazolo[5,1-a]phthalazine with an appropriate amine. The compounds are useful as bronchodilators.

REFERENCES:
patent: 4391806 (1983-07-01), Alexander et al.
patent: 4391807 (1983-07-01), Alexander et al.
Stanovnik et al., Synthesis 1977, (7), p. 491.
Stanovnik et al., Synthesis 1978, (1), p. 65.
Twomey, Proc. Roy. Ir. Acad., Sect. B 1974, 74 (4), 37.
Chem. Abstracts: vol. 86:171378j, Conalty et al.
Burger E. D., Medicinal Chemistry 3rd ed., Wiley-Interscience (1970), p. 76.
Karklina et al., Chem. Abstracts, vol. 81:37518y, (1974).

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