Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-05-01
2007-05-01
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S146000
Reexamination Certificate
active
10715662
ABSTRACT:
The invention is directed to physiologically active compounds of formula (I):wherein:R1represents optionally substituted aryl, optionally substituted heteroaryl, R3NH—Ar1—L2— or R3—NH—C(═O)—NH—Ar2—L2—; R3represents aryl or heteroaryl; Ar1represents a saturated, partially saturated or fully unsaturated 8- to 10-membered bicyclic ring system containing at least one heteroatom selected from O, S or N; Ar2represents aryldiyl or heteroaryldiyl; L1represents a linkage, such as an alkylene linkage; L2represents an alkylene chain linkage; R2represents hydrogen, halogen, C1-4alkyl or C1-4alkoxy; and Y is carboxy or an acid bioisostere;but excluding compounds where an oxygen, nitrogen or sulfur atom is attached directly to a carbon carbon multiple bond of an alkenylene or alkynylene residue;and the corresponding N-oxides and ester prodrugs thereof, and the pharmaceutically acceptable salts and solvates of such compounds, and the N-oxides and ester prodrugs thereof.Such compounds have valuable pharmaceutical properties, in particular the ability to regulate the interaction of VCAM-1 and fibronectin with the integrin VLA-4 (α4β1).
REFERENCES:
patent: 5236934 (1993-08-01), VanAtten
patent: 6608084 (2003-08-01), Bourzat et al.
Boger, et al., Inverse Electron Demand Diels-Alder reactions of 3-Carbomethoxy-2-pyrones. Controlled Introduction of oxygenated Aromatics: Benzene, Phenol, Catechol, Resorcinol, and Pyrogallol Annulation. Regiospecific Total Synthesis of Sendaverine and a Preparation of 6,7-Benzomorphans., J. Org. Chem.; vol. 49; No. 21; 1984; pp. 4033-4044.
Fenton Garry
Harris Neil Victor
Aventis Pharma Limited
Ori Ronald G.
Saeed Kamal A.
LandOfFree
Substituted tetrahydroisoquinolines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted tetrahydroisoquinolines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted tetrahydroisoquinolines will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3729990