Substituted tetra- and pentapeptide inhibitors of protein: farne

Details Substituted tetra- and pentapeptide inhibitors of protein: farne Substituted tetra- and pentapeptide inhibitors of protein: farne

1996-06-21

1998-06-09

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

4 to 5 amino acid residues in defined sequence

514 17, 514 18, A61K 3808

Patent

active

057635773

ABSTRACT:
Inhibitors of protein:farnesyl transferase enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer and restenosis.

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