Substituted terphenyl compounds for the treatment of inflammatio

Details Substituted terphenyl compounds for the treatment of inflammatio Substituted terphenyl compounds for the treatment of inflammatio

1994-11-29

1998-04-14

Burn, Brian M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514464, 514466, 514603, 514709, 514716, 514717, 549437, 549439, 549440, 549443, 549445, 564 86, 564 89, 568 33, 568 34, A61K 3118

Patent

active

057391661

ABSTRACT:
A class of terphenyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ##STR1## wherein each of R.sup.2 and R.sup.3 is independently selected from hydrido and halo; or wherein R.sup.2 and R.sup.3 together form --OCH.sub.2 O--; wherein each of R.sup.6 through R.sup.8 is independently selected from hydrido, lower alkyl, halo, lower alkoxy, lower haloalkyl, and lower dialkylamino; or wherein R.sup.6 and R.sup.7 together form --OCH.sub.2 O; and wherein R.sup.12 is selected from lower alkylsulfonyl and aminosulfonyl; or a pharmaceutically-acceptable salt thereof.

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