Substituted sulphoximines as TIE2 inhibitors and salts...

Details Substituted sulphoximines as TIE2 inhibitors and salts... Substituted sulphoximines as TIE2 inhibitors and salts...

2011-08-23

2011-08-23

Ward, Paul V. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S332000

Reexamination Certificate

active

08003655

ABSTRACT:
The invention relates to substituted sulphoximines according to the general formula (I):in which A, E, G, X, R1, R2, R3, R4, R5, R6, R7, R8, m, p, q, are given in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted sulphoximines, to methods of preparing said substituted sulphoximines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling.

REFERENCES:
patent: 2004/0102630 (2004-05-01), Brumby et al.
patent: WO 02/096888 (2002-12-01), None
patent: WO 03/066601 (2003-08-01), None
patent: WO 2005/037800 (2005-04-01), None
Pinedo et al., “Translational Research . . .”, The Oncologist 2000,, 5 (suppl1): 1-2 (www.The Oncologist .com).
McMahon, Gerald, “VEGF Receptor Signaling in Tumor Angiogenesis”, The Oncologist 2000; 5(suppl 1): 3-10 (www.The Oncologist.com).
Vippagunta et al., “Crystalline Solids”, Adv. Drug Del. Rev., 48 (2001) 3-26.

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