Substituted sulfonamide derivatives which inhibit allergic react

Details Substituted sulfonamide derivatives which inhibit allergic react Substituted sulfonamide derivatives which inhibit allergic react

1989-05-30

1991-11-12

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

514150, 534664, 534774, 534798, A61K 31655, A61K 3702

Patent

active

050646370

ABSTRACT:
The present invention involves intradermal, percutaneous, parenteral, or enteral administration of a newly synthesized compound to detect, reduce, or eliminate the occurrence of allergic reactions to sulfonamides. The new compound is a substituted sulfonamide, the substituent being bound to the paraamino (4-position) group through an azo, amide, or other linkage. Because a purpose of the substituent is to make the new compound water soluble, it can take a variety of forms, but it must contain carbon and hydrogen, plus at least one of oxygen and nitrogen. Examples of usable substituents include imidazole, a carbohydrate, or an amino acid such as histidine, tyrosine, tryptophan, lysine, or tyrosine methyl ester; it may also be a synthetic polymer, polypeptde, polysaccharide, or an amino acid homopolymer.

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