Substituted spirodienes for the treatment of inflammation

Details Substituted spirodienes for the treatment of inflammation Substituted spirodienes for the treatment of inflammation

1996-07-09

1997-09-30

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514604, 514708, 514709, 558413, 564 85, 564 89, 564 90, 568 27, 568 29, 568 32, 568 33, 568 35, A61K 31275, C07C25549, C07C30702, C07C31714

Patent

active

056726260

ABSTRACT:
A class of substituted spirodienes is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.4 and R.sup.5 is hydrido; wherein R.sup.3 is methylsulfonyl or sulfamyl; and wherein each of R.sup.6 through R.sup.10 is independently selected from hydrido, halo, alkyl, alkoxy, alkylthio, cyano, haloalkyl, haloalkoxy, hydroxyalkyl, alkoxyalkyl, hydroxyl, and mercapto; and wherein n is 1, 2 or 3; or a pharmaceutically-acceptable salt thereof.

REFERENCES:
patent: 4946993 (1990-08-01), Cortes
T. Hla and K. Neilson, Proc. Natl. Acad. Sci. USA, 89, 7384-7388 (1992).
J.L. Masferrer et al, Proc. Natl. Acad. Sci. USA, 89, 3917 (1992).
E. Meade et al, J. Biol. Chem., 268, 6610 (1993).
N. Futaki et al, Prostaglandins, 47, 1 (1994).
C. Allen et al, J. Org. Chem., 11, 268 (1946).
H. Zimmerman and J. Pincock, J. Amer. Chem. Soc., 95, 3246 (1973).
K. Hirao et al, J. Chem. Soc., Chem. Commun., 300 (1984).
M. Hamer and Stubs, J. Chem. Soc., D, 1013 (1970).

Affiliated with

Also associated with

Rating

Substituted spirodienes for the treatment of inflammation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted spirodienes for the treatment of inflammation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted spirodienes for the treatment of inflammation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2256922