Substituted spiro compounds for the treatment of inflammation

Details Substituted spiro compounds for the treatment of inflammation Substituted spiro compounds for the treatment of inflammation

1994-11-18

1998-04-07

O'Sullivan, Peter

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Sulfur, selenium or tellurium compound

514278, 514520, 514524, 514602, 514603, 514604, 514883, 514886, 546 15, 558412, 558413, 564 84, 564 85, 564 86, 564 89, 564 90, 568 29, 568 33, 568 34, A61K 3144, A61K 3118, A61K 3110

Patent

active

057365792

ABSTRACT:
A class of substituted spiro compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula III: ##STR1## wherein n is a number selected from 0, 1 and 2; wherein R.sup.3 is methylsulfonyl or sulfamyl; and wherein R.sup.8 is selected from hydrido, fluoro, chloro, bromo, iodo, methyl, ethyl, n-propyl, isopropyl, butyl, tert-butyl, isobutyl, methoxy, ethoxy, propoxy, butoxy, hydroxyl, mercapto, methylthio, ethylthio, cyano, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, trifluoromethoxy, hydroxymethyl, methoxymethyl and ethoxymethyl; or a pharmaceutically-acceptable salt thereof.

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