Substituted ring-fused imidazole derivative: GABAA receptors...

Details Substituted ring-fused imidazole derivative: GABAA receptors... Substituted ring-fused imidazole derivative: GABAA receptors...

2005-07-12

2005-07-12

Huang, Evelyn Mei (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S256000, C514S393000, C514S394000, C544S333000, C546S118000, C548S302700, C548S306100

Reexamination Certificate

active

06916827

ABSTRACT:
Substituted ring-fused imidazole derivatives that bind to GABAAreceptors are provided. Such compounds may be used to modulate ligand binding to GABAAreceptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAAreceptors (e.g., receptor localization studies).

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