Substituted quinolines and isoquinolines as calcium channel bloc

Details Substituted quinolines and isoquinolines as calcium channel bloc Substituted quinolines and isoquinolines as calcium channel bloc

1998-03-17

1999-08-03

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 95, A61K 31535, C07D49800

Patent

active

059325739

ABSTRACT:
The present invention relates to novel substituted quinolines and isoquinolines and derivatives thereof useful in the treatment of neurological disorders. Methods of preparing the compounds, intermediates useful in the preparation and pharmaceutical compositions containing the compounds are also included. The compounds are useful in treating pain, cerebral ischemia, and other cerebrovascular disorders.

REFERENCES:
Bowersox, et al., "Neuronal Voltage-Sensitive Calcium Channels", Drug News and Perspective, 7(5):261-268 (1994).
Yamada, et al., Chemical Abstract 96:85389p.
Shterev and Kaneti, Chemical Abstract 108:142832v.
Bourquin, et al., "Synthese von Estern halogenierter Chinaldine und Chinoline", Archiv der Pharmazie, 295(5):383-400 (1962).
Brack, "Antimikrobielle Wirkung von 8-Hydroxychinolin-Derivaten, besonders von einigen neuen Estern", Arzneimittel-Forsch. 12, 133-144 (1962).

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