Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-10-28
1990-02-27
Springer, David B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514300, 514311, 514314, 5142345, 544128, 546122, 546167, 546169, 546153, C07D21548, C07D40306, A61K 3147, A61K 31535
Patent
active
049046594
ABSTRACT:
The novel class of substituted quinolines represented by the general formula (I): ##STR1## where each of R.sub.1 and R.sub.2 separately represents H or up to three of the groups lower alkyl, halogen, CF.sub.3, CN, SO.sub.2 CH.sub.3, NO.sub.2, OH, NH.sub.2, NHSO.sub.2 R.sub.3, NHCOOR.sub.3, OR.sub.3, SR.sub.3, NHR.sub.3 or NR.sub.3 R.sub.3 (where R.sub.3 is lower alkyl optionally substituted with hydroxy, amino or ether functions), and each of R.sub.1 and R.sub.2 may additionally separately represent the substitution of an aza (--N.dbd.) group for one or two of the methine (--CH.dbd.) groups in each of the carbocyclic rings, and R.sub.1 may also represent, at positions 2', 3' or 4' only, a phenyl ring optionally further substituted with lower alkyl, halogen, CF.sub.3, CN, SO.sub.2 CH.sub.3, NO.sub.2, OH, NH.sub.2, NHCOR.sub.3, NHCOOR.sub.3, OR.sub.3, SR.sub.3, NHR.sub.3 or NR.sub.3 R.sub.3 (where R.sub.3 is lower alkyl optionally substituted with hydroxy, amino or ether functions);
REFERENCES:
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patent: 4567627 (1984-01-01), Miyano et al.
patent: 4680299 (1987-07-01), Hesson
Barker, Peter L., "Acylation of Dibasic Compounds Containing Amino Amidine and Aminoguanidine Functions", J. Org. Chem., vol. 46, No. 12, 1981, pp. 2455-2465.
Cain, Bruce F. "Potential Antitumor Agents. 23. 4'-(9-Acridinylamino) alkanesulfonanilide Congeners Bearing Hydrophilic Functionality", J. Med. Chem. vol. 20, No. 8, 1977, pp. 987-996.
Atwell Graham J.
Baguley Bruce C.
Denny William A.
Rewcastle Gordon W.
Development Finance Corporation of New Zeland
Springer David B.
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