Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-11-03
1989-08-15
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514260, 544 92, 544284, 544287, A61K 31505, C07D40112
Patent
active
048575305
ABSTRACT:
Novel 6-substituted-4(3H)-quinazolinones are described as well as methods for the preparation and pharmaceutical composition of same, which inhabit the enzyme thymidylate synthase (TS) and are thus useful as anticancer agents.
REFERENCES:
Jones, et al., Journal of Medicinal Chemistry, vol. 29, pp. 1114-1118 (1986).
Berman Ellen M.
McNamara Dennis J.
Werbel Leslie M.
Hollrah Glennon H.
Tinney Francis J.
Turnipseed James H.
Warner-Lambert & Company
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