Substituted quinazoline derivatives as inhibitors of aurora...

Details Substituted quinazoline derivatives as inhibitors of aurora... Substituted quinazoline derivatives as inhibitors of aurora...

2008-07-22

2008-07-22

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S284000

Reexamination Certificate

active

10499684

ABSTRACT:
The invention provides quinazoline derivatives of formula (I): in the preparation of a medicament for use in the inhibition of Aurora kinase and also novel quinazoline derivatives, processes for their preparation, pharamceutical compositions containing them and their use in therapy

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Wilkinson et al., “AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Including Apoptosis”, Clinical CAncer REsearch (2007), 3682-3688, 13(12).
Mortlock et al., “Discovery, Synthesis, and in Vivo Activity of a New Class of Pyrazolylaminoquinazolines as Selective Inhibitors of Aurora B Kinase”. Journal of Medicinal Chemistry (2007), 2213-2224, 50(9).
Heron et al., “SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors”. Bioorganic & Medicinal Chemistry Letters (2006), 1320-1323, 16(5).
Jung et al., “Discovery of Novel and Potent Thiazoloquinazolines as Selective Aurora A and B Kinase Inhibitors”. Journal of Medicinal Chemistry (2006), 955-970, 49(3).
Mortlock et al., “Progress in the Development of Selective Inhibitors of Aurora Kinases”. Current Topics in Medicinal Chemistry (2005), 807-821, 5(8).

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