Substituted quinazoline derivatives and their use as...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S266200, C514S266230, C514S266240, C544S119000, C544S284000, C544S293000

Reexamination Certificate

active

06919338

ABSTRACT:
The use of a compound of formula (I)or a salt, ester or amide thereof;where X is O, or S, S(O) or S(O)2, or NR6where R6is hydrogen or C1-6alkyl;R5is an optionally substituted 5-membered heteroaromatic ring,R1, R2, R3, R4are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase.Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed.

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patent: WO 99/35132 (1999-07-01), None
patent: WO 99/35146 (1999-07-01), None
patent: WO 00/21955 (2000-04-01), None
patent: WO 01/21597 (2001-03-01), None
Vinogradoff et al., CAPLUS Abstract 112:7444, 1990.
Golovkin et al., CAPLUS Abstract 115:78820, 1991.
Tanaka et al., PubMed Abstract (Cell 108(3):317-29), Feb. 2002.
Rogers et al., PubMed Abstract (J. Cell Biol. 157(2):219-29), Apr. 2002.
Simone, Oncology: Introduction, Cecil Textbook of Medicine, 20thEdition, vol. 1, pp. 1004-1010, 1996.

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