Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-07-03
2007-07-03
Shameem, Golam M. M. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S242000, C544S253000, C544S283000, C544S292000, C514S247000, C514S256000
Reexamination Certificate
active
10824731
ABSTRACT:
Compounds having the formula (I),are useful as p38 kinase inhibitors, wherein R4and R5are hydrogen, halogen, cyano, haloalkyl, or haloalkoxy, but are not both hydrogen; R6and R7are optional substituents, and Q is a non-aromatic moiety as defined in the specification.
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Wandel, et al, “P-Glycoprotein and Cytochrome P-450 3A Inhibition: Dissociation of Inhibitory Potencies1”, Cancer Research, Aug. 15, 1999, pp. 3944-3948, vol. 59:16.
Webb, et al., “Quinazolines as Adenosine Receptor Antagonists: SAR and Selectivity for A28Receptors”, Bioorganic & Medicinal Chemistry, (2003), pp. 77-85, vol. 11.
Hess, et al., “Antihypertensive 2-Amino-4(3H)-quinazolines”, Journal of Medicinal Chemistry, (1968), pp. 130-136, vol. 11:1.
Shewchuk, L., et al, “Binding Mode of the 4-Anilinoquinazoline Class of Protein Kinase Inhibitor: X-ray Crystallographic Studies of 4-Anilinoquinazolines Bound to Cyclin-Dependent Kinase 2 and p38 Kinase”, J. Med. Chem. 2000, 43:133-138 (XP002293111, compounds 1-3).
Dunn James Patrick
Goldstein David Michael
Stahl Christoph Martin
Trejo-Martin Teresa Alejandra
Green Grant D.
Roche Palo Alto LLC
Shameem Golam M. M.
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