Substituted quinazoline compounds useful as p38 kinase...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C544S242000, C544S253000, C544S283000, C544S292000, C514S247000, C514S256000

Reexamination Certificate

active

10824731

ABSTRACT:
Compounds having the formula (I),are useful as p38 kinase inhibitors, wherein R4and R5are hydrogen, halogen, cyano, haloalkyl, or haloalkoxy, but are not both hydrogen; R6and R7are optional substituents, and Q is a non-aromatic moiety as defined in the specification.

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Hess, et al., “Antihypertensive 2-Amino-4(3H)-quinazolines”, Journal of Medicinal Chemistry, (1968), pp. 130-136, vol. 11:1.
Shewchuk, L., et al, “Binding Mode of the 4-Anilinoquinazoline Class of Protein Kinase Inhibitor: X-ray Crystallographic Studies of 4-Anilinoquinazolines Bound to Cyclin-Dependent Kinase 2 and p38 Kinase”, J. Med. Chem. 2000, 43:133-138 (XP002293111, compounds 1-3).

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