Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-08-02
2011-08-02
Wilson, James O. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S284000, C546S148000, C546S268100, C548S136000, C548S159000, C548S247000, C548S361100, C548S373100, C548S469000
Reexamination Certificate
active
07989461
ABSTRACT:
The present invention comprises a new class of compounds capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula Iwherein R1isand A1, A2, A3, A4, X, Z, Z′, R1, R2, R3, R4, R5and R6are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
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Chen Jian J.
De Morin Frenel F.
Hitchcock Stephen
Liu Gang
Paras Nick A.
Amgen Inc.
Prabhakar Reddy G.
Willis Douglas M
Wilson James O.
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