Substituted pyrrolopyrimidines and pyridopyrimidines useful as a

Details Substituted pyrrolopyrimidines and pyridopyrimidines useful as a Substituted pyrrolopyrimidines and pyridopyrimidines useful as a

1994-08-08

1996-03-12

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514215, 540461, 540521, C07D48704, C07D47104, A61K 3155, A61K 31505

Patent

active

054987768

ABSTRACT:
This invention relates to pyrrolo-, pyrido-, azepino-, and azocinopyrimidines of the general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently H, lower alkyl containing 1 to 6 carbon atoms, or perfluoroalkyl containing 1 to 6 carbon atoms; R.sup.5 is H or, when n is 1, R.sup.5 taken together with R.sup.3 comprises a double bond, n is 0 or 1, p is 0 to 2, m is 0 to 3; Ar.sup.1 is ##STR2## wherein W is H, lower alkyl containing 1 to 6 carbon atoms, halogen, hydroxy, or lower alkoxy containing 1 to 6 carbon atoms; and Ar.sup.2 is ##STR3## wherein X is ##STR4## wherein R.sup.6 is H, tert-butyl, tri-n-butylstannyl, or triphenylmethyl; and the pharmaceutically acceptable salts thereof, which compounds are useful in the treatment of hypertension and congestive heart failure.

REFERENCES:
patent: 4880804 (1989-11-01), Carini
patent: 5039814 (1991-08-01), Shuman

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