Substituted pyrrolidines

Details Substituted pyrrolidines Substituted pyrrolidines

1993-09-20

1997-09-09

Haley, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514423, 5483147, 548531, 548536, 548538, 548542, A61K 3140, C07D20709

Patent

active

056657544

ABSTRACT:
Novel pyrrolidine compounds which are useful for inhibiting the function of Type IV phosphodiesterase (PDE-IV) as well as methods for making the same are disclosed. Applications in treating inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, are also disclosed.

REFERENCES:
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patent: 4219560 (1980-08-01), Houlihan
patent: 4960457 (1990-10-01), Woolard
patent: 5068245 (1991-11-01), Zipplies et al.
patent: 5068246 (1991-11-01), Zipplies et al.
patent: 5270328 (1993-12-01), Cantrell et al.
H. Yuki and M. Yatabe, "Pyrroles and Other 5-Membered Rings," Chemical Abstracts, abstract No. 72427, vol. 86, No. 11, p. 594, Mar. 1977.
S. Denmark and L. Marcin, "Nitroalkene [4+2] Cycloaddition as a General and Stereoselective Route to the Synthesis of 3,3-and 3,4-Disubstituted Pyrrolidines," J. Org. Chem., vol. 58, No. 25, pp. 3857-3868 (1993).
M. Marivet, et al., "Inhibition of Cyclic Adenosine-3',5'-monophosphate Phosphodiesterase from Vascular Smooth Muscle by Rolipram Analogues," J. Med. Chem., vol. 32, No. 7, pp. 1450-1457,1 1989.

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