Substituted pyrrolidine derivatives as HIV protease inhibitors

Details Substituted pyrrolidine derivatives as HIV protease inhibitors Substituted pyrrolidine derivatives as HIV protease inhibitors

1995-07-31

1996-09-03

Haley, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514314, 514343, 514423, 514319, 546169, 5462784, 546256, 5462791, 5462697, 548537, A61K 3140, C07D20709

Patent

active

055524052

ABSTRACT:
Disclosed herein are compounds of formula 1 ##STR1## wherein X is a terminal group, for example, an aryloxycarbonyl or an alkanoyl; B is absent or an amino acid residue, for example, Val or Asn; R.sup.1 is alkyl; and Y is a ring substituent, for example, benzyl, benzyloxy, phenylthio or 2-pyridinylthio. The compounds inhibit the activity of human immunodeficiency virus (HIV) protease and interfere with HIV induced cytopathogenic effects in human cells. These properties render the compounds useful for combating HIV infections.

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