Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-07-24
1999-04-06
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514415, 514422, 514427, 548455, 548466, 548469, 548517, 548518, 548530, A61K 3140, C07D20904
Patent
active
058919015
ABSTRACT:
Compounds of the formula ##STR1## wherein R is alkyl, alkylthio or hydroxy, as well as, pharmaceutically acceptable salts of compounds of formula I are antiproliferative agents useful in the treatment of cancer.
REFERENCES:
patent: 5057614 (1991-10-01), Davis et al.
patent: 5380746 (1995-01-01), Barth et al.
"Inhibitors of Protein Kinase C. 1. 2,3-Bisarylmaleimides," Peter D. Davis et al., J. Med. Chem., 1992, 35, pp. 177-184.
Am. J. Hygiene vol. 27, pp. 493-497, 1938.
Dhingra Urvashi Hooda
Huryn Donna Mary
Keith Dennis Dalton
Weber Giuseppe Federico
Hoffmann-La Roche Inc.
Johnston George W.
Oswecki Jane C.
Richter Johann
Rocha-Tramaloni Patricia S.
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