Substituted pyrrole derivatives as cell adhesion inhibitors

Details Substituted pyrrole derivatives as cell adhesion inhibitors Substituted pyrrole derivatives as cell adhesion inhibitors

1998-11-09

2000-07-18

Geist, Gary

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548412, 548537, A01N 4336, C07F 932, C07D20732

Patent

active

060908416

ABSTRACT:
Substituted pyrrole derivatives of Formula I are antagonists of VLA-4 and/or .alpha..sub.4 .beta..sub.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.

REFERENCES:
patent: 5510332 (1996-04-01), Kogan et al.
patent: 5605925 (1997-02-01), Martin et al.
Schroff, Hitesh N., et als. Bioorganic & Medicinal Chemistry Letters vol. 6, No. 21 pp. 2495-2500 (1996).
Jackson, David Y. et als. Med. Chem., 40 pp. 3359-3368 (1997).
Artico, et al., Pyrryl Aryl Sulfones. Arch Pharm., vol. 328, No. 3, pp. 223-229, 1995.

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