Substituted pyrimidoindoles and diazepinoindoles useful as hypog

Details Substituted pyrimidoindoles and diazepinoindoles useful as hypog Substituted pyrimidoindoles and diazepinoindoles useful as hypog

1987-05-22

1988-11-08

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514267, 540561, 544231, 544252, A61K 31505, A61K 3155, C07D48704

Patent

active

047834552

ABSTRACT:
Compounds of formula (I) ##STR1## and their pharmaceutically acceptable acid addition salts, wherein R represents lower alkyl or a mono- or bicyclic aryl or heteroaryl radical, R.sup.1 and R.sup.2 which may be the same or different each represent hydrogen, hydroxyl, lower alkyl, lower alkoxy, halo(lower)alkyl, halogen, amino or mono- or di(lower)alkylamino, X represents--CH.sub.2 CR.sup.3 R.sup.4 CH.sub.2 --or --(CH.sub.2).sub.4 --where R.sup.3 and R.sup.4 each independently represent hydrogen or lower alkyl or R.sup.3 and R.sup.4 together with the carbon atom to which they are attached represent a 5, 6 or 7 membered carbocyclic ring and R.sup.5 represents acyl and R.sup.6 represents hydrogen or R.sup.5 and R.sup.6 each independently represent hydrogen or lower alkyl, are useful as hypoglycaemics.

REFERENCES:
patent: 3634426 (1972-01-01), Eberle
patent: 3850957 (1974-11-01), White et al.
patent: 3891644 (1975-06-01), White

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