Substituted pyrimido[5,4-d]pyrimidine nucleosides

Details Substituted pyrimido[5,4-d]pyrimidine nucleosides Substituted pyrimido[5,4-d]pyrimidine nucleosides

1988-06-03

1991-08-20

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 26, 536 22, C07H 1923

Patent

active

050415425

ABSTRACT:
.alpha. and .beta.-ribonucleosides of substituted pyrimido[5,4-d]pyrimidines are used in treating malignant tumors in vivo. A novel synthesis for preparing these compounds and other related compounds is further disclosed.

REFERENCES:
patent: 4801698 (1989-01-01), Cook et al.
Goodman, "Chemical Synthesis and Transformations of Nucleosides" in Basic Principles in Nucleic Acid Chemistry, Ts'O ed., vol. 1, Academic Press, New York, 1974, pp. 152-161.
Cusack et al., J. Chem. Soc. Perkin I, 1973, pp. 1720-1731.
Westover et al., J. Med. Chem., 24, 941-946 (1981).
Berman et al., Tett. Lett., 1973 (33), pp. 3099-3101.

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