Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-12-04
2000-08-01
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142278, 5142358, 514249, 514255, 514275, 544 60, 544123, 544238, 544295, 544296, 544297, 544319, 544320, 544321, 544326, 544328, A61K 31506, A61K 31513, A61P 1900, C07D23924
Patent
active
060967536
ABSTRACT:
Selected novel substituted pyrimidinone and pyridone compounds are effective for prophylaxis and treatment of diseases, such as TNF-.alpha., IL-1.beta., IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
REFERENCES:
patent: 3929807 (1975-12-01), Fitzi
patent: 4578459 (1986-03-01), Durant et al.
patent: 4990512 (1991-02-01), Perrior et al.
patent: 5100897 (1992-03-01), Allen et al.
patent: 5162325 (1992-11-01), Chakravarty et al.
patent: 5298481 (1994-03-01), Tice
patent: 5300477 (1994-04-01), Tice
patent: 5434157 (1995-07-01), Wierenga et al.
patent: 5518994 (1996-05-01), Kawamura et al.
Mirkin et al., J. of the American Chemical Society, vol. 112(7), 2809-10 (1990).
Komatsu et al., Tetrahedron Letters, vol. 22(38), 3769-72 (1981).
Ohshiro et al., Heterocycles, vol. 22(3), 549-59 (1984).
Mortimer, Australian Journal of Chemistry, vol. 21(2), 467-76 (1968).
Takahashi et al., Chemistry Letters, No. 6, 1229-32 (1987).
Magdesieva et al., Chemistry of Heterocyclic Compounds, vol. 13(9), 1177-80 (1978).
Youssefyeh et al., Journal of the Chemical Society, No. 23, 2649-54 (1974).
Barr et al., Journal of the Chemical Society, No. 5, 1147-9 (1980).
Capuano et al., Liebigs Annalen Der Chemie, No. 4, 331-4 (1991).
Gilchrist et al., Journal of the Chemical Society, No. 19, 1969-72 (1975).
Gilchrist et al., Journal of the Chemical Society, No. 12, 487-8 (1974).
Giammanco et al., Atti Della Accademia di Scienze Lettere E Arti Di Palermo, vol. 30, 93-107 (1971).
Giammanco et al., Annali di Chimica, vol. 60(3), 188-97 (1970).
Giammanco, Atti Della Accademia di Scienze Lettere E Arti Di Palermo, vol. 27, 469-83 (1968).
Patent Abstracts of Japan, vol. 10(230), Publication No. 61 063680 (1996).
Yerxa et al., Tetrahedron, vol. 50(21), 6173-80 (1994).
Kotani et al., Tetrahedron, vol. 30(17), 3027-30 (1974).
STN printout for Eicher et al., Reaction of Diphenylcyclopropenone with Guanidines, Liebigs Ann. Chem., vol. 8, pp. 1337-1353, 1981.
STN printout for Jones et al., N-Oxides, N-imides, and N-ylides of Five-Membered Heterocycles, J. Chem. Sci., Perkin Trans. 1, vol. 21, pp. 2259-2264, 1976.
STN printout for Yoshida et al., The Cycloaddition Reaction of N-imidoyl Sulfoximides with Diphenylcyclopropenone to Yield Pyrimidinone or Pyrrolinone Derivatives, Bull. Chem. Soc. Japan, vol. 56, No. 8, pp. 2438-2441, 1983.
STN printout for Takahashi et al., Synthesis of 3-Substituted 5,6-Diphenylpyrimidin-4-ones from Diphenylcyclopropenone and N-substituted Amide Oximes, Heterocycles, vol. 22, No. 3, pp. 581-584, 1984.
Agathocleous and Shaw, J. Chem. Soc. Perkin Trans. I, 2555 (1993).
Baracos et al., New Eng. J. Med., 308, 553 (1983).
Bayer and Hartmann, Arch. Pharm. (Wwinheim) 324, 815 (1991).
Benneche et al., Acta Chem Scand. B 42, 384-389 (1988).
Bennett et al., J. Med. Chem. 21, 623 (1978).
Berge et al., J. Pharm. Sci. 66, 1 (1977).
Beutler et. al., J. Immunol. 135, 3969 (1985).
Beyaert et al., EMBO Journal 1996, vol. 15, p 1914-23.
Brahn et al., Lymphokine Cytokine Res. 11, 253 (1992).
Bredereck et. al., Chem. Ber. 97, 3407-3417 (1964).
Brown, D. J., Heterocyclic Compounds: the Pyrimidines, Chapter 3, 1994, John Wiley & Sons.
Chandrasekhar et al., Clinical Immunol. Immunopathol. 55, 382 (1990).
Clouse et al., J. Immunol. 142, 431 (1989).
Cooper, Clin. Exp. Immunol. 89, 244 (1992).
Courtenay, J. S., Nature (1980), vol. 283, p 666.
Davies et al., J.Chem.Soc., Chem.Commun., 1153 (1993).
Dinarello, Eur. Cytokine Netw. 5, 517-531 (1994).
Efimovsky and Rumpf, Bull. Soc. Chim. FR. 648-649 (1954).
El-Rayyes and Al-Hajjar, J. Heterocycl. Chem. 21, 1473 (1984).
Firestein, Am. J. Pathol. 140, 1309 (1992).
Folks et al., J. Immunol. 136, 40 (1986).
Gallagher et al, Biorg. Med. Chem. Lett. 1995, 1171-1176.
Hronowski and Szarek, Can. J. Chem. 63, 2787 (1985).
Joosten et al, Arthritis & Rheumatism 39:797-809 (1996).
Kabbe, Lieb. Ann. Chem. 704, 144 (1967).
Katritzky and Rachwal, J. Heterocyclic Chem. 32, 1007 (1995).
Lahdevirta et al., Am. J. Med. 85, 289 (1988).
Lee et al, Circulatory Shock 44:97-103 (1995).
Lee et al., Nature 372:739 (1994).
Legrand and Lozac'h, Bull. Soc. Chim. Fr., 79-81 (1955).
Liu et al., Neurosci. Lett. 164, 125 (1993).
Liu et al., Stroke 25, 1481 (1994).
Maini et al., Immunological Reviews, pp. 195-223 (1995).
Mathes and Sauermilch, Chem. Ber. 88, 1276-1283 (1955).
Peters et al., J. Heterocyclic Chem. 27, 2165-2173 (1990).
Sakasi et al., Heterocycles 13, 235 (1978).
Sandosham and Undheim, Acta Chem. Scand. 43, 684-689 (1989).
Shaw and Warrener, J. Chem. Soc. 153-156 (1958).
Shohami et al., J. Cereb. Blood Flow Metab. 14. 615 (1994).
Simchen, G., Chem. Ber. 103, 389-397 (1970).
Stanonis, J. Org. Chem. 22, 475 1957).
Swingle, K. F., in R. A. Scherrer and M. W. Whitehouse, Eds., Antiinflammatory Agents, Chemistry and Pharmacology, vol. 13-II, Academic, New York, 1974, p. 33-122, Chapter 2.
Trentham et al J. Exp. Med. (1977) vol. 146, p 857.
Wheeler, Journal of Labelled Compounds and Radiopharmaceuticals, vol. XXXI, No. 4, pp. 305-312 (1992).
Winter et al Proc. Soc. Exp. Biol. Med. (1962) vol. 111, p 544.
Baldwin et al (Synlett. 51-53, 1993).
Basha and Debernardis Tetrahedron Lett, vol. 25, 5271, 1984.
Brunner et al., Eur. J. Med. Chem. 25, 35-44, 1990.
Bundgaard J. Med. Chem., vol. 32, 2503 (1989).
Cohen and S. Y. Weinstein, J. Am. Chem. Soc. 86, 725-728, 1964.
Davies and I.A.S. Walters, J. Chem. Soc. Perkin Trans.I, 1129-1139 (1994).
Dornow and Fust, Chem. Ber. 87, 985, 1954.
Freifelder and R. B. Hasbrouck, J. Am. Chem. Soc. 82, 696-698, 1960.
Hendry et al Tetrahedron Lett, vol. 28, 4597 (1987).
Kojima and J. Fujita, Bull. Chem. Soc. Jpn. 55, 1454-1459, 1982.
Konieczny and Cushman Tetrahedron Lett, vol. 33, 6939, 1992.
Lang, et al., Endocrinol. 130, 43-52, 1992.
Leanna et al., Tetrahedron Lett., vol. 34, No. 28, 4485 (1993).
Mitchell and T.M. Koenig, Synth. Comm. 25 (8), 1231-1238, 1995.
Svensson and Tunek, Drug Metabolism Reviews, vol. 19(2), 165 (1988).
Szalkowski et al., Endocrinol. 136, 1474-1481, 1995.
Ten Hoeve and H. Wynberg, Synth. Commun. 24 (15), 2215-2221, 1994.
Dey et al., Tetrahedron, vol. 51, No. 27, pp. 7459-7468 (1995).
Takahashi et al., Heterocycles, vol. 22, No. 3, pp. 581-584 (1984).
Yoshida et al., Bulletin of the Chemical Society of Japan, vol. 56, No. 8, pp. 2438-2441 (1983).
Malone Michael J.
Mantlo Nathan B.
Spohr Ulrike D.
Amgen Inc.
Coleman Brenda
Levy Ron
Odre Steven
Shah Mukund J.
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