Substituted pyrimidines as ligands of adenosine receptors

Details Substituted pyrimidines as ligands of adenosine receptors Substituted pyrimidines as ligands of adenosine receptors

2004-10-01

2008-11-11

Balasubram, Venkataraman (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S326000, C544S329000

Reexamination Certificate

active

07449470

ABSTRACT:
The invention provides a compound of formula (I) wherein R and R′ are selected from hydrogen, alkyl, alkenyl, alkynyl, or aryl; R″ and R′″ are selected from hydrogen, acyl, thio-acyl, seleno-acyl, alkyl, alkenyl, alkynyl, or aryl; or a pharmaceutically acceptable salt thereof, to interact with the adenosine receptors in the beneficial treatment and/or prevention of a (dis)order arising from the said receptors. The invention further provides pharmaceutical compositions comprising said compounds. The invention also relates to the use of said compositions for treating an/or preventing a variety of diseases.

REFERENCES:
patent: 4725600 (1988-02-01), Takaya et al.
patent: 5138058 (1992-08-01), Geisen et al.
patent: 6156755 (2000-12-01), Geisen
patent: 6518424 (2003-02-01), John et al.
patent: 6562811 (2003-05-01), Murata et al.
patent: 6586441 (2003-07-01), Borroni et al.
patent: 6716851 (2004-04-01), Cai et al.
patent: 6844347 (2005-01-01), Schnidler et al.
patent: 2003/0078271 (2003-04-01), Blackburn et al.
patent: 0767170 (1997-04-01), None
patent: 1439175 (2004-07-01), None
patent: 06192252 (1994-07-01), None
patent: 11158073 (1999-06-01), None
patent: 2001089452 (2001-04-01), None
patent: 2001199982 (2001-07-01), None
patent: 2003206230 (2003-07-01), None
patent: WO9824782 (1998-06-01), None
patent: WO0147921 (2001-07-01), None
patent: WO0222602 (2002-03-01), None
patent: WO03049739 (2003-06-01), None
patent: WO03068757 (2003-08-01), None
patent: WO03077656 (2003-09-01), None
patent: WO2004014307 (2004-02-01), None
patent: WO2004048365 (2004-06-01), None
patent: WO2005058883 (2005-06-01), None
Henze et al., J. Amer. Chem. Soc., 79, 2230-2232, 1957.
Fredholm, B.B. et al, International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors. Pharmacological Reviews 2001, 527-552, 53.
Van Galen, P.J. et al, Imidazo[4,5-c]quinolin-4-amines: Novel Xanthine Adenosine Agonists. Journal of Medicinal Chemistry, 1991, 1202-1206, 34.
Sarges, R. et al, 4-Amino[1,2,4]triazolo[4,3-a]quinazolines. A Novel Class of Potent Adenosine Receptor Antagonists and Potential Rapid-Onset Antidepressants. Journal of Medicinal Chemistry, 1990, 2240-2254, 33.
Baraldi, P. G. et al, Pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine Derivatives: potent and Selective A2a Adenosine Antagonists. Journal of Medicinal Chemistry, 1996, 1164-1171, 39.
Baraldi, P. G. et al, Pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine Derivatives as Highly Potent and Selective A3 Adenosine Receptor Antagonists: Influence of the Chain at the N8 Pyrazolem Nitrogen. Journal of Medicinal Chemistry, 2000, 4748-4780, 43.
Hess, S. et al. &-Deazaadenines Bearing Polar Substituents; Structure-Activity Relationships of New A1 and A3 Adenosine Receptor Antagonists. Journal of Medicinal Chemistry, 2000, 4636-4646, 43.
De Valk, J. et al, On the Mechanism of the Amination of 2-Bromo-2,6-diphenyl-pyrimidine with Potassium Amide in Liquid Ammonia. Recueil, 1973, 155-163, 92.
Brown, D.J. et al, Heterocyclic Amplifiers of Phenomycin. I. Some Pyrimidinylpurines, Pyrimidinylpterdines and Phenylpyrimidines. Journal of Chemistry, 1984, 155-163, 37.
Priego, E. M. et al, Pyrido[2,1-f]purine-2,4-dione Derivatives as a Novel Class of Highly Potent A3 Adenosine Receptor Antagonists. Journal Of Medicinal Chemitry, 2002, 3337-3344, 45.
Farouk H. et al: “Reaction of alpha,beta-unsaturated ketones with guanidine. Substituent effects on the protonation constants of 2-amino-4,6-diarylpyrimidines.” J Heterocyclic Chem., 1982, 1087-1092, 19.
Henze et al., Researches on Pyrimidines: Certain Derivatives of 2-Propylpyrimidine, J.Amer. Chem. Soc. 1957, 2230-2232, 79.
Lardenois, Patrick et al, Tautomerie des composes heterocycliques. Bulletine de la Societe de Chimique de France, 1971, 1858-1868.
Chapman, N.B. et al, Nucleophilic Displacement Reaction in Aromatic Systems Part III. J Chem Soc .,1954, 1190-1192.
Wheeler, Henry L., Researches on Pyrimidins: On Some Salts of Cytosin, Isocytosin, 6-Aminopyrimidin and 6-Oxypyrimidin, J Biol Chem 1907, 285-297, 3.
El-Shenawy, A.I. et al, Synthesis of Some Heterocyclic Compounds Bearing a Maleimido Moiety, Egyptian Journal of Chemistry, 2002, 895-904, 45.
Gotor, Vincente et al, Synthesis and Rearrangement of 5-Isocyanatopyrazolines, Tetrahedron, 1989, 1783-1792, 45.
Bredereck, Helmut et al, Trisacylaminomethane: Synthesen and Umsetzungen, Chem Ber, 1963, 1505-1514, 96.
Mamaev, V.P. et al, New Method for the Synthesis of 2-Aminopyrimidines, Chem. Heterocycl. Compd. 1975, 1322-1324, 11.

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