Substituted pyrimidine derivatives, a process for the preparatio

Details Substituted pyrimidine derivatives, a process for the preparatio Substituted pyrimidine derivatives, a process for the preparatio

1991-08-08

1993-06-01

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544295, C07D40300, A61K 31495, A01N 4360

Patent

active

052159906

ABSTRACT:
Pyrimidine derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2, X and Y have the stated meaning, the salts thereof and a process for the preparation thereof are described. Because of their sorbitol-accumulating activity, they are suitable for use as reagents for an advantageous pharmacological screening model for testing aldose reductase inhibitors.

REFERENCES:
patent: 2362276 (1944-11-01), Jayne, Jr.
patent: 2973362 (1961-02-01), Schorsch
patent: 3190883 (1965-07-01), Geschickter et al.
patent: 3296261 (1967-01-01), Partyka
P. J. Brown, "The Pyrimidines" (1962) pp. 31, 36, 50, 162-165, 186-188.

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