Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-02-01
2009-06-23
Desai, Rita J (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S355000
Reexamination Certificate
active
07550489
ABSTRACT:
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
REFERENCES:
patent: 4746680 (1988-05-01), Jeffery et al.
patent: 4929629 (1990-05-01), Jeffery
patent: 4956380 (1990-09-01), Toda et al.
patent: 4973587 (1990-11-01), Ward et al.
patent: 5013837 (1991-05-01), Ward et al.
patent: 5081122 (1992-01-01), Ward
patent: 5102667 (1992-04-01), Dubroeucq et al.
patent: 5112820 (1992-05-01), Ward
patent: 5278316 (1994-01-01), Horwell et al.
patent: 5292736 (1994-03-01), Kumar et al.
patent: 5436272 (1995-07-01), Scheinbaum
patent: 5532237 (1996-07-01), Gallant et al.
patent: 5597797 (1997-01-01), Clark
patent: 5624941 (1997-04-01), Barth et al.
patent: 5707987 (1998-01-01), Nakagawa et al.
patent: 5795895 (1998-08-01), Anchors
patent: 5908830 (1999-06-01), Smith et al.
patent: 6011048 (2000-01-01), Mathvink et al.
patent: 6011174 (2000-01-01), Iwasawa et al.
patent: 6028084 (2000-02-01), Barth et al.
patent: 6121325 (2000-09-01), Chen et al.
patent: 6258837 (2001-07-01), Fukami et al.
patent: 6335345 (2002-01-01), Fukami et al.
patent: 6344474 (2002-02-01), Maruani et al.
patent: 6344481 (2002-02-01), Cornelius et al.
patent: 6355631 (2002-03-01), Achard et al.
patent: 6359175 (2002-03-01), Philippe et al.
patent: 6479479 (2002-11-01), Achard et al.
patent: 6509367 (2003-01-01), Martin et al.
patent: 2002/0006964 (2002-01-01), Young et al.
patent: 2002/0010192 (2002-01-01), Coe et al.
patent: 2002/0062022 (2002-05-01), Sabb et al.
patent: 2002/0091114 (2002-07-01), Piot-Grosjean et al.
patent: 2003/0114495 (2003-06-01), Finke et al.
patent: 2004/0058820 (2004-03-01), Hagmann et al.
patent: 2004/0122033 (2004-06-01), Nargund et al.
patent: 2004/0248956 (2004-12-01), Hagmann et al.
patent: 2005/0288213 (2005-12-01), MacNeil et al.
patent: 2006/0148721 (2006-07-01), Erondu
patent: 2006/0160834 (2006-07-01), Fong et al.
patent: 2006/0270650 (2006-11-01), MacNeil et al.
patent: 2007/0099884 (2007-05-01), Erondu et al.
patent: 4332738 (1995-03-01), None
patent: 0163607 (1985-05-01), None
patent: 0611749 (1994-08-01), None
patent: 0 920 864 (1999-06-01), None
patent: 0658546 (2001-05-01), None
patent: 1302461 (2003-04-01), None
patent: 1-156957 (1989-06-01), None
patent: 3-176469 (1991-07-01), None
patent: 3-220168 (1991-09-01), None
patent: 03220168 (1991-09-01), None
patent: 8-165276 (1996-06-01), None
patent: 9-505601 (1997-03-01), None
patent: WO 95/11880 (1995-05-01), None
patent: WO 95/23150 (1995-08-01), None
patent: WO 96/18391 (1996-06-01), None
patent: WO 96/33159 (1996-10-01), None
patent: WO 96/40912 (1996-12-01), None
patent: WO 97/06816 (1997-02-01), None
patent: WO 97/16189 (1997-05-01), None
patent: WO 97/17321 (1997-05-01), None
patent: WO 97/18833 (1997-05-01), None
patent: WO 97/29078 (1997-08-01), None
patent: WO 97/29079 (1997-08-01), None
patent: WO 97/46250 (1997-12-01), None
patent: WO 98/18481 (1998-05-01), None
patent: WO 98/28427 (1998-07-01), None
patent: WO 98/31227 (1998-07-01), None
patent: WO 98/32441 (1998-07-01), None
patent: WO 98/33765 (1998-08-01), None
patent: WO 98/37061 (1998-08-01), None
patent: WO 98/41519 (1998-09-01), None
patent: WO 98/43635 (1998-10-01), None
patent: WO 98/43636 (1998-10-01), None
patent: WO 98/56754 (1998-12-01), None
patent: WO 99/02499 (1999-01-01), None
patent: WO 99/37667 (1999-07-01), None
patent: WO 00/10967 (2000-03-01), None
patent: WO 00/10968 (2000-03-01), None
patent: WO 00/37462 (2000-06-01), None
patent: WO 00/66578 (2000-11-01), None
patent: WO 00/076493 (2000-12-01), None
patent: WO 01/01969 (2001-01-01), None
patent: WO 01/09120 (2001-02-01), None
patent: WO 01/92229 (2001-06-01), None
patent: WO 01/52825 (2001-07-01), None
patent: WO 01/58450 (2001-08-01), None
patent: WO 01/58869 (2001-08-01), None
patent: WO 01/64632 (2001-09-01), None
patent: WO 01/64633 (2001-09-01), None
patent: WO 01/64634 (2001-09-01), None
patent: WO 01/70700 (2001-09-01), None
patent: WO 01/85092 (2001-11-01), None
patent: WO 01/87849 (2001-11-01), None
patent: WO 02/12168 (2002-02-01), None
patent: WO 02/19998 (2002-03-01), None
patent: WO 02/20488 (2002-03-01), None
patent: WO 02/22592 (2002-03-01), None
patent: WO 02/28346 (2002-04-01), None
patent: WO 02/32897 (2002-04-01), None
patent: WO 02/38551 (2002-05-01), None
patent: WO 02/49648 (2002-06-01), None
patent: WO 02/060427 (2002-08-01), None
patent: WO 02/060428 (2002-08-01), None
patent: WO 02/068388 (2002-09-01), None
patent: WO 02/076949 (2002-10-01), None
patent: WO 03/006007 (2003-01-01), None
patent: WO 03/007887 (2003-01-01), None
patent: WO 03/020217 (2003-03-01), None
patent: WO 03/026647 (2003-04-01), None
patent: WO 03/026648 (2003-04-01), None
patent: WO 03/027068 (2003-04-01), None
patent: WO 03/027069 (2003-04-01), None
patent: WO 03/027076 (2003-04-01), None
patent: WO 03/027114 (2003-04-01), None
patent: WO 03/037332 (2003-05-01), None
patent: WO 03/040107 (2003-05-01), None
patent: WO 03/082190 (2003-10-01), None
patent: WO 03/082191 (2003-10-01), None
patent: WO 03/086288 (2003-10-01), None
patent: WO 03/087037 (2003-10-01), None
patent: WO 2004/012671 (2004-02-01), None
patent: WO 2004/029204 (2004-04-01), None
patent: WO 2004/048317 (2004-06-01), None
patent: WO 2004/058145 (2004-07-01), None
patent: WO 2004/058741 (2004-07-01), None
patent: WO 2004/058744 (2004-07-01), None
patent: WO 2004/060870 (2004-07-01), None
patent: WO 2005/000809 (2005-01-01), None
patent: WO 2005/009479 (2005-02-01), None
patent: WO 2005/027837 (2005-03-01), None
patent: WO 2006/036770 (2006-04-01), None
patent: WO 2006/049933 (2006-05-01), None
Abele et al., Helv. Chim. Acta, vol. 81 (1998), pp. 2141-2156, “(S):β3-Homolysine- and (S)-β3-homoserine-containing β-peptides: . . .”.
Hintermann et al., Helv. Chim. Acta, vol. 81, (1998), pp. 2093-2126, “A useful modification of the Evans auxiliary: . . .”.
D'Souza et al., J. Chem. Soc. Perkin Trans., vol. 1 (1995), pp. 1-2, “(R)-(+)-3-Amino-2-(phenylpropanoic acid: . . .”.
Gutierrez-Garcia et al., J. Braz. Chem. Soc., vol. 12 (2001), pp. 652-660, “Enantioselective synthesis of β-Amino acids . . .”.
Adam et al., Exp. Opin. Ther. Patents, vol. 12 (2002), pp. 1475-1489, “Recent advances in the cannabinoids”.
Goya et al., Exp. Opin. Ther. Patents, vol. 10 (2000), pp. 1529-1538, “Recent advances in cannabinoid receptor agonists and antagonists”.
Grundy, Exp opin. Investig. Drugs, vol. 11 (2002), pp. 1365-1374, “The therapeutic potential of the cannabinoids in neuroprotection”.
Di Marzo et al., Emerging Thera. Targets, vol. 5 (2001), pp. 241-265, “Endocannabinoids Part I: Molecular bais of endocannabinoid formation, . . .”.
Petitet et al., Emerging Drugs, vol. 3 (1998), pp. 39-53, “The therapeutic applications of cannabinoid agonists and antagonists”.
Barth, Exp. Opin. Ther. Patents, vol. 8 (1998), pp. 301-313, “Cannabinoid receptor agonists and antagonists”.
Batkai et al., Nature Medicine, vol. 7 (2001), pp. 827-832, “Endocannabinoids acting at vascular CB, receptors mediate the vasodilated . . .”.
Vizi et al., Eur. J. Pharmacol., vol. 431 (2001), pp. 237-244, “Evidence for presynaptic cannabinoid CB1 receptor-mediated
Armstrong Helen M.
Chang Linda L.
Guthikonda Ravindra N.
Hagmann William K.
Jewell James P.
Brown Baerbel R.
Desai Rita J
Fitch Catherine D.
Merck & Co. , Inc.
LandOfFree
Substituted pyridyoxy amides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted pyridyoxy amides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted pyridyoxy amides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4107407