Substituted pyrido[3,2-d]pyrimidines capable of inhibiting tyros

Details Substituted pyrido[3,2-d]pyrimidines capable of inhibiting tyros Substituted pyrido[3,2-d]pyrimidines capable of inhibiting tyros

1997-03-06

2000-07-04

Gupta, Yogendra N.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544235, 544253, C07D48704

Patent

active

060840951

ABSTRACT:
Novel 4-substituted amino pyrido [3,2-d]pyrimidine inhibitors of epidermal growth factor receptor family of tyrosine kinases are described, as well as pharmaceutical compositions of the same, which are useful in treating proliferative diseases such as cancer, synovial pannus invasion in arthritis, psoriasis, vascular restenosis and angiogenesis and additionally useful in the treatment of pancreatitis and kidney disease as well as a contraceptive agent.

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