Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2001-09-25
2003-10-28
Desai, Rita (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S358000, C546S194000, C546S339000, C546S347000
Reexamination Certificate
active
06638946
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to new substituted pyridine or piperidine compounds and to their use as facilitators of memory and cognition and as antalgic agents.
BACKGROUND OF THE INVENTION
Ageing of the population due to increased life expectancy has brought with it a major increase in cognitive disorders associated with normal cerebral ageing and with pathological cerebral ageing occurring in the course of neurodegenerative diseases such as, for example, Alzheimer's disease.
The majority of substances used today in treating cognitive disorders associated with ageing act by facilitating the central cholinergic systems—either directly, as in the case of acetylcholinesterase inhibitors (tacrine, donepezil) and cholinergic agonists (nefiracetam), or indirectly, as in the case of nootropic agents (piracetam, pramiracetam) and cerebral vasodilators (vinpocetine).
Besides their cognitive properties, substances acting directly on the central cholinergic systems often have antalgic properties but also have hypothermic properties, which can be undesirable.
It has been therefore been especially valuable to synthesise new compounds that are capable of opposing the cognitive disorders associated with ageing and/or of improving cognitive processes and that can possess antalgic properties without having hypothermic activity.
DESCRIPTION OF THE PRIOR ART
The literature discloses substituted piperidine compounds which are described as products of synthesis and/or of alkaloids (J. Chem. Soc., Perkin Trans. 1, 1991, (3), pp. 611-616; Heterocycles, 1985, 23 (4), pp. 831-834; Can. J. Chem., 1996, 74 (12), pp. 2444-2453).
Substituted pyridine compounds have also been described with reference to their synthesis (J. Chem. Soc., Dalton Trans., 1998, (6), pp. 917-922) or their interactions in metal complexes (J. Chem. Soc., Chem. Commun., 1987, (19), pp. 1457-1459; J. Am. Chem. Soc., 1985, 107 (4), pp. 917-925).
The compounds of the present invention are new and have properties that, from a pharmacological point of view, are especially valuable.
REFERENCES:
patent: 5633257 (1997-05-01), Warrelow et al.
patent: 5830904 (1998-11-01), Crooks et al.
patent: 99-02497 (1997-01-01), None
patent: WO 99/02497 (1999-01-01), None
Caplus 132:193986, English abstract, Jeyaraman R. et al Journal Of Indian chem. Society 1999.*
Caplus 131:228624, English Abstract, Nasakin O.E. et al Chem. of heterocyclic Compounds. 1998 vol. 34, issue 10 pp. 1177-1180.
Caignard Daniel-Henri
Lebrun Marie-Cécile
Lestage Pierre
Meth-Cohn Otto
Renard Pierre
Desai Rita
Les Laboratoires Servier
The Firm of Hueschen and Sage
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