Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-03-02
2010-10-12
Anderson, Rebecca L (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S131000
Reexamination Certificate
active
07812020
ABSTRACT:
The present invention relates to pyridine derivatives of the general formula (I) and their use as openers of the KCNQ family potassium ion channels for the treatment of CNS disorders.
REFERENCES:
patent: 554543 (1993-08-01), None
patent: 97/15300 (1997-05-01), None
patent: 01/10380 (2001-02-01), None
patent: 01/22953 (2001-04-01), None
patent: 01/92526 (2001-12-01), None
patent: 01/96540 (2001-12-01), None
patent: 02/49628 (2002-06-01), None
patent: 02/066036 (2002-08-01), None
patent: 2004/082677 (2004-09-01), None
patent: 2005/087754 (2005-09-01), None
Jentsch, T. J. Nature Reviews 2000, 1, pp. 21-30.
Wu et al. Biorg. Med. Chem. Lett. 2004, 14, p. 4533-4537.
Albericio, F., et al. Coupling Reagents and Activation. In Methods in Enzymology: Solid-Phase Peptide Synthesis. New York: Academic Press. 1997. pp. 104-126.
Berge, S. M., et al. Pharmaceutical Salts. Journal of Pharmaceutical Sciences. 1977. 66(1):1-19.
Bialer, M., et al. Progress Report on New Antiepileptic Drugs: A Summary of the Sixth Eilat Conference (EILAT VI). Epilepsy Research. 2002. 51:31-71.
Blackburn-Munro, G., et al. The Anticonvulsant Retigabine Attenuates Nociceptive Behaviours in Rat Models of Persistent and Neuropathic Pain. European Journal of Pharmacology. 2003. 460:109-116.
Bundgaard, H. ed. Designs of Prodrugs. New York: Elsevier. 1985.
Capacio, B. R., et al. Use of The Accelerating Rotarod For Assessment of Motor Performance Decrement Induced by Potential Anticonvulsant Compounds in Nerve Agent Poisoning. Drug and Chemical Toxicology. 1992. 15(3):177-201.
Casser, L. A New Nickel-Catalyzed Synthesis of Aromatic Nitriles. Journal of Organometallic Chemistry. 1973. 54: C57-058.
Clark, W. M., et al. A Highly Enantioselective Conjugate Reduction of 3-Arylinden-1-ones Using Bakers' Yeast for the Preparation of (S)-3-Arylindan-1-ones. Organic Letters. 1999. 1(11):1839-1842.
Clark, W. M., et al., A Catalytic Enantioselective Synthesis of The Endothelin Receptor Antagonists SB-209670 and SB-217242. A Base-Catalyzed Stereospecific Formal 1,3-Hydrogen Tranfer of a Chiral 3-Arylindenol. J. Am. Chem. Soc. 1998. 120:4550-4551.
Cooper, E. C., et al. M-Channels: Neurological Diseases, Neuromodulation, and Drug Development. Arch. Neurol. 2003. 60(4):496-500.
Cooper, E. C., et al. M Channel KCNQ2 Subunits Are Localized to Key Sites for Control of Neuronal Network Oscillations and Synchronization in Mouse Brain. The Journal of Neuroscience. 2001. 21(24):9529-9540.
Cooper, E. C., et al. Colocalization and Coassembly of Two Human Brain M-Type Potassium Channel Subunits That Are Mutated in Epilepsy. Proceedings of the National Academy of Sciences USA. 2000. 97(9):4914-4919.
de la Mare, P.B.D., et al. Preparative Methods of Nitration, In Aromatic Substitution. London: Butterworths Scientific Publications. 1959. pp. 48-56.
Dohle, W., et al. Copper-Mediated Cross-Coupling of Functionalized Arylmagnesium Reagents with Functionalized Alkyl and Benzylic Halides. Organic Letters. 2001. 3(18):2871-2873.
Ebert, U., et al. Delayed Sclerosis, Neuroprotection, and Limbic Epileptogenesis After Status Epilepticus in the Rat. Epilepsia. 2002. 43(Suppl. 5):86-95.
Gennaro, Alfonso, R. ed. Remington: The Science and Practice of Pharmacy. 19th Edition. Mack Publishing Co. Easton, PA. 1995.
Goldstein, M.E., et al. Localization of KCNQ and KCNE Channel Subunits in the Central and Peripheral Nervous System of the Rat. Program No. 53.8. 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2003. Online.
Greene, T.W., et al. Protective groups in organic synthesis. 2nd ed. Hoboken, NJ: Wiley Interscience. 1991.
Hamill O. P., et al. Improved Patch-Clamp Techniques for High-Resolution Current Recording From Cells and Cell-Free Membrane Patches. Pflugers Arch. 1981. 391:85-100.
Hartz. B. P., et al. The KCNQ Channel Opener Retigabine Has Anxiolytic Properties. [Abstract] Journal of Psychopharmacology. 2003. 17(suppl 3):A28, B14.
Jacques, J., et al. Enantiomers, Racemates and Resolutions. New York: John Wiley & Sons. 1981.
Jensen, B.S. BMS-204352: A Potassium Channel Opener Developed for the Treatment of Stroke. CNS Drug Rev. 2002. 8(4):353-60.
Jentsch, T. J. Neuronal KCNQ Potassium Channels: Physiology and Role in Disease. Nature Reviews Neuroscience. 2000. 1:21-30.
Keeney, A. J., et al. Alterations in Core Body Temperature, Locomotor Activity, and Corticosterone Following Acute and Repeated Social Defeat of Male NMRI Mice. Physiology and Behaviour. 2001. 74:177-184.
Kimball, A.W., et al. Chemical Protection Against Ionizing Radiation: I. Sampling Methods for Screening Compounds in Radiation Protection Studies With Mice. Radiation Research. 1957. 7:1-12.
Kubisch, C., et al. KCNQ4, A Novel Potassium Channel Expressed in Sensory Outer Hair Cells, Is Mmutated in Dominant Deafness. Cell. 1999. 96(3):437-446.
Lecocq J. Quelques Nouveaux Derives de la p-Amino-Benzene-Sulfonylamide et de la 4-4′-Diamino-Diphenyl-Sulfone. Bull. Soc. Chim. Fr. 1950. 46:188-192. [w/ Eng. Abstract].
Lerche, C., et al. Molecular Cloning and Functional Expression of KCNQ5, A Potassium Channel Subunit That May Contribute to Neuronal M-Current Diversity. J Biol Chem. 2000. 275(29):22395-22400.
Marrion, Neil V. Control of M-Current. Annual Review of Physiology. 1997. 59:483-504.
Mitsunobu, O. The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products. Synthesis. Jan. 1981. pp. 1-28.
Mongin F., et al. Advances in the Directed Metallation of Azines and Diazines (Pyridines, Pyrimidines, Pyrazines, Pyridazines, Quinolines, Benzodiazines and Carbolines). Part 1: Metallation of Pyridines, Quinolines and Carbolines. Tetrahedron. 2001. 57:4059-4090.
Negishi, E.-I., et al. The Ortho Lithiation of Tertiary Benzamides. J. Org. Chem. 1977. 42(10):1823-1824.
Noda, M., et al. KCN Channels in Glial Cells. Program No. 53.9. 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2003. Online.
Nutt, D.J., et al. Optimizing the Pentetrazol Infusion Test for Seizure Threshold Measurement. J. Pharm. Pharmacol. 1986. 38:697-698.
Racine, R. J. Modification of Seizure Activity by Electrical Stimulation: II. Motor Seizure. Electroencephalography and Clinical Neurophysiology. 1972. 32:281-294.
Robbins, J. KCNQ Potassium Channels: Physiology, Pathophysiology, and Pharmacology. Pharmacology & Therapeutics. 2001. 90:1-19.
Rogawski, M. A. KCNQ2/KCNQ3 K+ Channels and the Molecular Pathogenesis of Epilepsy: Implications for Therapy. Trends in Neurosciences. 2000. 23(9):393-398.
Rostock, A., et al. D-23129: A New Anticonvulsant With a Broad Spectrum Activity in Animal Models of Epileptic Seizures. Epilepsy Research. 1996. 23:211-223.
Saganich, M. J. et al. Differential Expression of Genes Encoding Subthreshold-Operating Voltage-Gated K+ Channels in Brain. Journal of Neuroscience. 2001. 21(13):4609-4624.
Schroder, R. L., et al. Voltage-Independent KCNQ4 Currents Induced by (±) BMS-204352. Pflugers Arch.—European J. Physiology. 2003. 446(5):607-616.
Schroder,R. L., et al. KCNQ4 Channel Activation by BMS-204352 and Retigabine. Neuropharmacology. 2001. 40:888-898.
Siegel, S. Heterogeneous Catalytic Hydrogenation of C=C and Alkynes. In Comprehensive Organic Synthesis. New York: Pergamon Press. 1991. 8:417-442.
Sonogashira, K., et al. A Convenient Synthesis of Acetylenes: Catalytic Substitutions of Acetylenic Hydrogen With Bromoalkenes, lodoarenes, and Bromopyridines. Tet. Lett. 1975. 16(50):4467-4470.
Starr, M. S., et al. Paradoxical Facilitation of Pilocarpine-Induced Seizures in the Mouse by MK-801 and the Nitric Oxide Synthesis Inhibitor L-NAME. Pharmacology Biochemistry and Behavior. 1993. 45:321-325.
Tang, W., et al. Development and Evaluation of High Throughput Functional Assay Methods for hERG Potassium Channel. J. Biomol. Screen. 2001. 6(5):325-331.
Tatulian, L., et al. Activation of Expressed KCNQ Potassium Currents and Native Neuronal M-Type Potassium Currents by the Anti-Convulsant Drug Retigabine. J Neuroscience. 2001. 21(15):5535-5545.
Tober, C., et al. D-23129: A Potent
Greve Daniel Rodriguez
Khanzhin Nikolay
Rottländer Mario
Tornøe Christian Wenzel
Watson William Patrick
Anderson Rebecca L
Coughlin Matthew P
H. Lundbeck A/S
LandOfFree
Substituted pyridine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted pyridine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted pyridine derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4223087