Substituted pyridine compounds and methods of use

Details Substituted pyridine compounds and methods of use Substituted pyridine compounds and methods of use

1998-11-03

2000-02-08

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546297, 546298, 546289, 546288, 546290, A61K 3144, C07D21360

Patent

active

060228849

ABSTRACT:
Selected novel substituted pyridine compounds are effective for prophylaxis and treatment of diseases, such as TNF-.alpha., IL-1.beta., IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

REFERENCES:
patent: 3375257 (1968-03-01), Thiele et al.
patent: 3513171 (1970-05-01), Thiele et al.
patent: 3539639 (1970-11-01), Mrozik et al.
patent: 3712900 (1973-01-01), Thiele et al.
patent: 3819639 (1974-06-01), Delarge et al.
patent: 3929807 (1975-12-01), Fitzi
patent: 3980652 (1976-09-01), Delarge et al.
patent: 3991057 (1976-11-01), Delarge et al.
patent: 4002629 (1977-01-01), Delarge et al.
patent: 4094982 (1978-06-01), Morisawa et al.
patent: 4149872 (1979-04-01), Pilgram
patent: 4241068 (1980-12-01), Schromm et al.
patent: 4888047 (1989-12-01), Milano et al.
patent: 4983600 (1991-01-01), Ward et al.
patent: 5236948 (1993-08-01), Waterson
patent: 5312820 (1994-05-01), Ashton et al.
patent: 5380734 (1995-01-01), Hsu et al.
patent: 5593992 (1997-01-01), Adams et al.
patent: 5596008 (1997-01-01), Lee
patent: 5610320 (1997-03-01), Yoshino et al.
patent: 5665724 (1997-09-01), Sanfilippo et al.
patent: 5756524 (1998-05-01), Riordan et al.
patent: 5843868 (1998-12-01), Tonishi et al.
Baracos, et al., The New Engand Journal of Medicine, vol. 308, p. 553 (1983).
Berge et al., Journal of Pharmaceutical Sciences, vol. 66, No. 1, pp. 1 (1977).
Beutler et al., Journal of Immunology, vol. 135, p. 3969 (1985).
Brahn et al., Lymphokine and Cytokine Research, vol. 11, pp. 253 (1992).
Brunner et al., Eur. J. Med. Chem., vol. 25, pp. 35 (1990).
Bundgaard et al., J. Med. Chem., vol. 32, p. 2503 (1989).
Chandraesekhr et al., Clinical Immunology and Immuopathology, vol. 55, pp. 382-400 (1990).
Clouse et al., Journal of Immunology, vol. 142 pp. 431-438 (1989).
Colbry et al., J. Heterocyclic Chem., vol. 21, pp. 1521 (1984).
Cooper et al., Clin. Exp. Immunol., vol. 89, pp. 244 (1992).
Courtenay et al., Nature, vol. 283, pp. 666 (1980).
Davies et al., J. Chem. Soc., Chem. Commun., pp. 1153 (1993).
Dinarello, Eur. Cytokine Netw., vol. 5, pp. 517-531 (1994).
Dornow et al., Chem. Ber 87, pp. 985 (1954).
Firestein et al., American Journal of Pathology, vol. 140, p. 1309 (1992).
Folks et al., Journal of Immunology, vol. 136, pp. 4049 (1986).
Freifelder et al., J. Am. Chem. Soc., vol. 82, pp. 696 (1959).
Grussenmeyer et al., PNAS USA, vol. 82, pp. 7952-7954 (1985).
Kaiser, Tetahedron, vol. 39, pp. 2055 (1983).
Kojima et al., Bull. Chem. Soc. Jpn., vol. 55, pp. 1454 (1982).
Lahdevirta et al., The American Journal of Medicine, vol. 85, p. 289 (1988).
Lang et al., Endocrinilogy, vol. 130, p. 43 (1992).
Liu et al., Stroke, vol. 25, p. 1481 (1994).
Maini et al., Immunological Reviews, vol. 144, p. 195 (1995).
Matsumoto et al., J. Heterocyclic Chem., vol. 21, pp. 673 (1984).
Nishigaki et al., Chem. Pharm. Bull, vol. 17:9, pp. 1827 (1969).
Shohami et al., J. Cereb. Blood Flow Metab., vol. 14, No. 4, p. 615 (1994).
Svensson et al., Drug Metabolism Reviews, vol. 19,(2), pp. 165 (1988).
Swingle, Antiinflammatory Agents, Edited by Robert Scherrer and Michael Whitehouse, vol. II, Ch. 2, pp. 33-122 (1974).
Szalkowski et al., Endrocrinology, vol. 136, p. 1474 (1995).
Trentham et al., Journal of Experimental Medicine, vol. 146, pp. 857 (1977).
Wheeler et al., Journal of Labelled Compounds and Radiopharmaceuticals, vol. XXXI, No. 4, pp. 305 (1992).
Williams et al., PNAS USA, vol. 89, pp. 2922-2926 (1992).
Winter et al., Proc. Soc. Exp. Biol. Med., vol. 111, pp. 544 (1962).
Liu et al., Neuroscience Letters, vol. 164, pp. 125-128 (1993).
Lee et al., Circulatory Shock, vol. 44, pp. 97-103 (1995).
Beyaert et al., EMBO Journal, vol. 15, pp. 1914-1923 (1996).
Joosten et al., Arthritis & Rheumatism, vol. 39, pp. 797-809 (1996).
Delarge, Farmaco-Ed. Sc., vol. 29, pp. 101-108 (1974).

Affiliated with

Also associated with

Rating

Substituted pyridine compounds and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted pyridine compounds and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted pyridine compounds and methods of use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1681717