Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-03-08
1992-09-29
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514252, 514253, C07D23714
Patent
active
051514206
ABSTRACT:
Substituted benzylideneiminophyenylpyridazinones or dihydropyridazinones of formula I ##STR1## in which R.sub.1 and R.sub.8 independently mean hydrogen or lower alkyl, R2 is hydrogen, lower alkyl, trifluoromethyl, hydroxy alkyl, halogen alkyl, alkoxy alkyl, pyridyl, furyl, thienyl or cycloalkyl or one of optionally substituted groups; aryl, aralkyl, aralkenyl or nitrogen containing heterocyclic ring joining through an alkyl or alkenyl group and R.sub.3, R.sub.4 and R.sub.5 independently mean hydrogen, lower alkyl, hydroxy alkyl, halogen, hydroxy, alkoxy, acyloxy, aroyloxy, formyl, acyl, cyano, amino, carboxy or trifluoromethyl, R.sub.6 and R.sub.7 independently mean hydrogen, amino, lower alkyl, hydroxy, nitro or cyano or R.sub.2 and R.sub.7 together form a --CH.sub.2 --NH-- or --CH.dbd.N-- group and A means phenyl, naphtyl or a nitrogen containing heterocyclic ring. The compounds may be used in the treatment of congestive heart failure.
REFERENCES:
patent: 4289774 (1981-09-01), Schact et al.
patent: 4521415 (1985-06-01), Katakami
patent: 4946849 (1990-08-01), Coates et al.
patent: 4954501 (1990-09-01), Herter
patent: 5019575 (1991-05-01), Hakala et al.
H. Okushima et al., J. Med. Chem. 30(7), 1157-61 (1987), "A Novel Class of Cardiotonics . . . ".
Chemical Abstracts, vol. 97, p. 653, No. 55827h, 1982.
Chemical Abstracts, vol. 103, p. 142000, No. 141996m, 1985.
Backstrom Reijo J.
Haikala Heimo O.
Heinola Kalevi E.
Honkanen Erkki J.
Nore Pentti T.
Daus Donald G.
Orion Corporation/Orion Pharmaceutica
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