Substituted pyrazolopyridines and salts thereof,...

Details Substituted pyrazolopyridines and salts thereof,... Substituted pyrazolopyridines and salts thereof,...

2007-06-12

2010-12-07

Seaman, D. Margaret (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S252160, C514S303000, C546S118000, C544S117000, C544S362000

Reexamination Certificate

active

07846928

ABSTRACT:
The invention relates to substituted pyrazolopyridines according to the general formula (I):in which A, B, D, E, Ra, R1, R2, R3, R4, R5and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted pyrazolopyridine compounds, to methods of preparing said substituted pyrazolopyridines, as well as to uses thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling.

REFERENCES:
patent: 02/060900 (2002-08-01), None
patent: WO 2004/113304 (2004-12-01), None
patent: WO 2006/050109 (2006-05-01), None
patent: WO 2007/000241 (2007-01-01), None
D. Albert et al., “Preclinical Activity of ABT-869, A Multitargeted Receptor Tyrosine Kinase Inhibitor,” Mol. Cancer Therapeutics, vol. 5, No. 4, (Apr. 2006) pp. 995-1006.

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