Substituted pyrazolo[3,4-d]pyrimidinone derivatives

Details Substituted pyrazolo[3,4-d]pyrimidinone derivatives Substituted pyrazolo[3,4-d]pyrimidinone derivatives

2007-04-25

2010-11-16

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S234500, C514S262100, C544S262000, C544S117000

Reexamination Certificate

active

07834019

ABSTRACT:
The invention relates to compounds of a general formula (I):wherein Ar1is an optionally-substituted aryl or heteroaromatic group; R1is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3is a hydrogen atom or a lower alkyl group; R4is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc.The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.

REFERENCES:
patent: WO0043394 (2000-07-01), None
patent: WO 2004/056786 (2004-07-01), None
patent: WO 2005/021532 (2005-03-01), None
patent: WO2006074985 (2006-07-01), None
patent: WO 2006/091737 (2006-08-01), None
patent: WO2007126122 (2007-11-01), None

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