Substituted pyrazolo[3,4-d]pyrimidines as PI3K inhibitors

Details Substituted pyrazolo[3,4-d]pyrimidines as PI3K inhibitors Substituted pyrazolo[3,4-d]pyrimidines as PI3K inhibitors

2011-04-05

2011-04-05

Moore, Susanna (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S262000, C544S280000, C514S265100

Reexamination Certificate

active

07919498

ABSTRACT:
Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukemia (AML) Myelodysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

REFERENCES:
Berndt, et al., “The p110δ structure: Mechanisms for selectivity and potency of new PI(3)K inhibitors” Nature Chemical Biology, Jan. 10, 2010 pp. 1-8.
Berndt, et al., “Supplementary Methods and Results The p110δ structure: Mechanisms for selectivity and potency of new PI(3)K inhibitors” Nature Chemical Biology, Jan. 2010 pp. 1-34.

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