Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S406000, C546S120000, C548S375100

Reexamination Certificate

active

07915286

ABSTRACT:
The present invention relates to phosphodiesterase (PDE) type IV selective inhibitors. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type IV selective inhibitors are provided. Prepared compounds correspond to structure XIV Formula (XIV).

REFERENCES:
patent: 3312590 (1967-04-01), Elks et al.
patent: 3436389 (1969-04-01), Giangiacomo et al.
patent: 3506694 (1970-04-01), Oxley et al.
patent: 3639434 (1972-02-01), Oxley et al.
patent: 3642896 (1972-02-01), Collin et al.
patent: 3644353 (1972-02-01), Lunts et al.
patent: 3652554 (1972-03-01), Anner et al.
patent: 3700681 (1972-10-01), Barth
patent: 3705233 (1972-12-01), Lunts et al.
patent: 3721687 (1973-03-01), Elks et al.
patent: 3780177 (1973-12-01), Ercoli et al.
patent: 3928326 (1975-12-01), Brattsand et al.
patent: 3929768 (1975-12-01), Brattsand et al.
patent: 3937838 (1976-02-01), Wetterlin et al.
patent: 3947478 (1976-03-01), Woods et al.
patent: 3980778 (1976-09-01), Ayer et al.
patent: 3983233 (1976-09-01), Brattsand et al.
patent: 3992534 (1976-11-01), Brattsand et al.
patent: 3994974 (1976-11-01), Murakami et al.
patent: 4011258 (1977-03-01), Wetterlin et al.
patent: 4014909 (1977-03-01), Torossian et al.
patent: 4076708 (1978-02-01), Green et al.
patent: 4081541 (1978-03-01), Bertelli
patent: 4098803 (1978-07-01), Torossian et al.
patent: 4124707 (1978-11-01), Green et al.
patent: 4158055 (1979-06-01), Shultz et al.
patent: 4226862 (1980-10-01), Riva et al.
patent: 4242334 (1980-12-01), Stache et al.
patent: 4290962 (1981-09-01), Tachi et al.
patent: 4298604 (1981-11-01), Hammell et al.
patent: 4335121 (1982-06-01), Phillipps et al.
patent: 4419364 (1983-12-01), Olsson et al.
patent: 4472392 (1984-09-01), Anderson et al.
patent: 4579985 (1986-04-01), Minderhoud et al.
patent: 4587236 (1986-05-01), Annen et al.
patent: 4619921 (1986-10-01), Kalvoda et al.
patent: 4780469 (1988-10-01), Toda et al.
patent: 4826868 (1989-05-01), Wachter et al.
patent: 4859692 (1989-08-01), Bernstein et al.
patent: 4873259 (1989-10-01), Summers, Jr. et al.
patent: 4992474 (1991-02-01), Skidmore et al.
patent: 5015746 (1991-05-01), Mizushima et al.
patent: 5126375 (1992-06-01), Skidmore et al.
patent: 5243076 (1993-09-01), Skidmore et al.
patent: 5278156 (1994-01-01), Mizushima et al.
patent: 5482934 (1996-01-01), Calatayud et al.
patent: 5565473 (1996-10-01), Belley et al.
patent: 5583152 (1996-12-01), Bernstein et al.
patent: 5837699 (1998-11-01), Sequeira et al.
patent: 5889015 (1999-03-01), Sequeira et al.
patent: 5976573 (1999-11-01), Kim
patent: 6057307 (2000-05-01), Sequeira et al.
patent: 6107301 (2000-08-01), Aldrich et al.
patent: 6127353 (2000-10-01), Yuen et al.
patent: 6180781 (2001-01-01), Yuen et al.
patent: 6337324 (2002-01-01), Harmenberg et al.
patent: 6339099 (2002-01-01), Lam et al.
patent: 6723713 (2004-04-01), Sequeira et al.
patent: 2003/0176421 (2003-09-01), Watson et al.
patent: 2004/0167030 (2004-08-01), Bernotas et al.
patent: 2004/0176325 (2004-09-01), Munson et al.
patent: 2004/0180896 (2004-09-01), Munson et al.
patent: 2004/0192653 (2004-09-01), Munson et al.
patent: 2005/0208582 (2005-09-01), Ohi et al.
patent: 2010/0292196 (2010-11-01), Rudra et al.
patent: 0 068 806 (1983-01-01), None
patent: 0 542 356 (1991-11-01), None
patent: 0 542 355 (1993-05-01), None
patent: 0 419 049 (1995-04-01), None
patent: 0 773 023 (1997-05-01), None
patent: 1 040 829 (2000-10-01), None
patent: 1 040 831 (2000-10-01), None
patent: 1 059 100 (2000-12-01), None
patent: 1 097 709 (2001-05-01), None
patent: 1 149 583 (2001-10-01), None
patent: 1 251 128 (2002-10-01), None
patent: WO 93/05021 (1993-03-01), None
patent: WO 95/10506 (1995-04-01), None
patent: WO 95/34563 (1995-12-01), None
patent: WO 97/48697 (1997-12-01), None
patent: WO 97/49702 (1997-12-01), None
patent: WO 98/09961 (1998-03-01), None
patent: WO 98/57951 (1998-12-01), None
patent: WO 99/23076 (1999-05-01), None
patent: WO 99/23077 (1999-05-01), None
patent: WO 00/15222 (2000-03-01), None
patent: WO 00/42045 (2000-07-01), None
patent: WO 00/59902 (2000-10-01), None
patent: WO 01/19798 (2001-03-01), None
patent: WO 01/23389 (2001-04-01), None
patent: WO 01/58489 (2001-08-01), None
patent: WO 02/18383 (2002-03-01), None
patent: WO 02/22604 (2002-03-01), None
patent: WO 02/22606 (2002-03-01), None
patent: WO 02/24694 (2002-03-01), None
patent: WO 02/50070 (2002-06-01), None
patent: WO 02/051832 (2002-07-01), None
patent: WO 02/051837 (2002-07-01), None
patent: WO 02/060900 (2002-08-01), None
patent: WO 02/081463 (2002-10-01), None
patent: WO 03/024969 (2003-03-01), None
patent: WO 03/047520 (2003-06-01), None
patent: WO 03/064397 (2003-08-01), None
patent: WO 03/068773 (2003-08-01), None
patent: WO 2004/009600 (2004-01-01), None
patent: WO 2004/014368 (2004-02-01), None
patent: WO 2004/024728 (2004-03-01), None
patent: WO 2004/028481 (2004-04-01), None
patent: WO 2004/037814 (2004-05-01), None
patent: WO 2004/056823 (2004-07-01), None
patent: WO 2004/076450 (2004-09-01), None
patent: WO 2004/080463 (2004-09-01), None
patent: WO 2004/096130 (2004-11-01), None
patent: WO 2004/108133 (2004-12-01), None
patent: WO 2005/009389 (2005-02-01), None
patent: WO 2005/009958 (2005-02-01), None
patent: WO 2005/021515 (2005-03-01), None
patent: WO 2005/028480 (2005-03-01), None
patent: WO 2005/058892 (2005-06-01), None
patent: WO 2005/063767 (2005-07-01), None
patent: WO 2005/077955 (2005-08-01), None
patent: WO 2005/082367 (2005-09-01), None
patent: WO 2005/085248 (2005-09-01), None
patent: WO 2005/085249 (2005-09-01), None
patent: WO 2005/100353 (2005-10-01), None
patent: WO 2005/111038 (2005-11-01), None
patent: WO 2006/001894 (2006-01-01), None
patent: WO 2006/004188 (2006-01-01), None
patent: WO 2006/009245 (2006-01-01), None
patent: WO 2006/013095 (2006-02-01), None
patent: WO 2006/023704 (2006-03-01), None
patent: WO 2006/046023 (2006-05-01), None
patent: WO 2006/047415 (2006-05-01), None
patent: WO 2006/047516 (2006-05-01), None
patent: WO 2006/050076 (2006-05-01), None
patent: WO 2006/050109 (2006-05-01), None
patent: WO 2006/058074 (2006-06-01), None
patent: WO 2006/058120 (2006-06-01), None
patent: WO 2006/060456 (2006-06-01), None
patent: WO 2006/060535 (2006-06-01), None
Sutherland and Rall, “The Relation of Adenosine-3′, 5′-Phosphate and Phosphorylase to the Actions of Catecholamines and Other Hormones”,Pharmacological Reviews, 12(3):265-299 (1960).
Beavo and Reifsnyder, “Primary Sequence of Cyclic Nucleotide Phosphodiesterase Isozymes and the Design of Selective Inhibitors”,Trends in Pharmacological Sciences, 11(4):150-155 (1990).
Nicholson et al., “Differential Modulation of Tissue Function and Therapeutic Potential of Selective Inhibitors of Cyclic Nucleotide Phosphodiesterase Isoenzymes”,Trends in Pharmacological Sciences, 12:19-27 (1991).
Verghese et al., “Anti-Neutrophil Activity of Cyclic Nucleotide Phosphodiesterase Inhibitors with Varying Cardiotonic Potencies”,Journal of Molecular and Cellular Cardiology, 12(Suppl. II):S61 (1989).
Zhang et al., “Phosphodiesterase-4 as a Potential Drug Target”,Expert Opinion on Therapeutic Targets, 9(6):1283-1305 (2005).
Houslay et al., “Keynote Review: Phosphodiesterase-4 as a therapeutic target”,Drug Discovery Today, 10(22):1503-1519 (2005).
Lambrecht et al., “Pharmacology of Hexahydro-Difenidol, Hexahydro-sila-Difenidol and Related Selective Muscarinic Antagonists”,Trends in Pharmacol. Sci., 10(Suppl):60-64 (1989).
Birdsall et al., “Muscarinic Receptor Subclasses”,Trends in Pharmacol. Sci., 4:459 (1983).
Coruzzi et al., “Gastric Antisecretory Activity of Telenzepine, a New M1-Selective Muscarinic With Pirenzepine”,Arch. Int. Pharmacodyn. Ther., 302:232-241 (1989).
Kawashima et al., “Pharmacological Differentiation of Presynaptic M1 Muscarinic Receptors Modulating Acetylcholine Release From Postsynaptic Muscarinic Receptors in Guinea-Pig Ileum”,Gen. Pharmacol., 21(1):17-21 (1990).
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