Substituted pyrazolo[1,5-a]pyrimidines as metabotropic...

Details Substituted pyrazolo[1,5-a]pyrimidines as metabotropic... Substituted pyrazolo[1,5-a]pyrimidines as metabotropic...

2011-05-24

2011-05-24

Moore, Susanna (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S281000

Reexamination Certificate

active

07947689

ABSTRACT:
The invention relates to pyrazolopyrimidine derivatives of formula (I)whereinY1, Y2and Y3independently are e.g. CR10, NH, S or O,whereby at least one of Y1, Y2and Y3represents CR10;R1represents chloro or bromo;R2, R3, R4, R5, R6and R7represent e.g. hydrogen or C1-C6-alkyl, andR10represents e.g. hydrogen, halogen or phenyl;which are potent mGluR5 modulators and are e.g. useful for the treatment of various neurological disorders.

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