Substituted pyrazoles suitable as p38 kinase inhibitors

Details Substituted pyrazoles suitable as p38 kinase inhibitors Substituted pyrazoles suitable as p38 kinase inhibitors

1999-04-01

2000-07-11

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

5142355, 5142372, 514255, 514318, 514341, 546193, 546194, 546211, 5462754, C07D40104, C07D40304, C07D41304, A61K 3144, A61K 31445, A61K 315377

Patent

active

060874961

ABSTRACT:
A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula I: ##STR1## wherein R.sup.1, R.sup.2, Ar.sup.1 and HetAr.sup.2 are as described in the specification.

REFERENCES:
patent: 3254093 (1966-05-01), Huisgen et al.
patent: 3984431 (1976-10-01), Gueremy et al.
patent: 4000281 (1976-12-01), Beiler et al.
patent: 5051518 (1991-09-01), Murray et al.
patent: 5134142 (1992-07-01), Matsuo et al.
patent: 5559137 (1996-09-01), Adams et al.
patent: 5589439 (1996-12-01), Goto et al.
patent: 5932576 (1999-08-01), Anantanarayan et al.
Sep. 25, 1998 PCT International Search Report (PCT/US98/10807.
Moerck et al, J. Chem. Soc., Chem. Commun. No. 19, 1974, pp. 782-783.
DannHardt et al, Arch. Pharm., vol. 321, No. 1, 1988, pp. 17-19.

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