Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-10-04
2005-10-04
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S243000, C540S599000, C544S184000
Reexamination Certificate
active
06951851
ABSTRACT:
Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described.
REFERENCES:
patent: 4500525 (1985-02-01), Winters et al.
patent: 5264576 (1993-11-01), Shutske et al.
patent: 5739153 (1998-04-01), Peignier et al.
patent: 5776718 (1998-07-01), Palmer et al.
patent: 5856514 (1999-01-01), Peignier et al.
patent: 5976858 (1999-11-01), Palmer et al.
patent: 6030946 (2000-02-01), Klaus et al.
patent: 6287840 (2001-09-01), Palmer et al.
patent: 0254241 (1988-01-01), None
patent: 382637 (1993-07-01), None
patent: 502788 (1996-04-01), None
patent: 655248 (1999-09-01), None
patent: 1 489 280 (1975-01-01), None
patent: S50-116470 (1974-03-01), None
patent: S52-14765 (1975-07-01), None
patent: WO 94/29276 (1994-12-01), None
patent: WO 95/23222 (1995-08-01), None
patent: WO 96/30353 (1996-10-01), None
patent: WO 97/21439 (1997-06-01), None
patent: WO 97/40066 (1997-10-01), None
patent: WO 9858785 (1998-12-01), None
patent: WO 99/24460 (1999-05-01), None
patent: WO 99/48911 (1999-09-01), None
patent: WO 99/58153 (1999-11-01), None
patent: WO 00/49008 (2000-08-01), None
patent: WO 00/51998 (2000-09-01), None
patent: WO 00/55144 (2000-09-01), None
patent: WO 01/09110 (2001-02-01), None
patent: WO 01/19796 (2001-03-01), None
patent: WO 01/40204 (2001-06-01), None
Andronati, “Synthesis of 3-aryl-1-[4-phenyl-1-piperazinyl)butyl]indazole derivatives and their affinity to 5-HT1Aserotonin and dopamine D1receptors” Pharmazie 54 (1999) 2, pp. 99-101.
Palmer, J. T. et al.; “Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors”; J. Med. Chem. (1995) 38(17):3193-3196.
Bromme, D. et al.; “Peptidyl vinyl susphones: a new class of potent and selective cysteine protease inhibitors”; Biochem. J. (1996) 315:85-89.
McGrath, M.E. et al.: “Crystal structure of human cathespin S”: Protein Science (1998) 7:1294-1302.
Nerenberg, J. B. et al.; “Design and Synthesis of N-Alkylated Saccharins as Selective a-1A Adrenergic Receptor Antagonists”: Bioorg. Med. Chem. Lett. (1998) 8:2467-2472.
Honey, K. et al.; “Role of Lysosomal Cysteine Proteinases in Antigen Presentation to CD4 T Cells”; Inflammation Research (2001) Sup.3, vol. 50, pS159 abstr. 1C '01.
Li, W. et al.; “Tissue Specific Expression of Cathepsins and Antigen Presentation”; Inflammation Research (2001) Sup 3, vol. 50 p S159 abstr. 10/02.
Magill, C. et al.; “Cysteine Proteases in Antigen Presentation and Models of Inflammation”; Inflammation Research (2001) Sup 3, vol. 50, p S159. abstr. 10/03.
Allen, E.M. et al.; “Reversible Cathepsin S (CATS) Inhibitors Block Invariant Chain Degradation Both In Vitro and In Vivo”; Inflammation Research (2001) Sup 3. vol. 50. p S159, abstr. 10/04.
Podolin, P. L. et al.; “Inhibition of Cathepsin S Blocks Invariant Chain Processing and Antigen-induced Proliferation in Vitro, and Reduces the Severity of Collagen-induced Arthritis in Vivo”; Inflammation Research (2001) Sup. 3, vol. 50, p S159, abstr. 10/05.
Spero, D. et al.; “Design and Synthesis of Novel Cathepsin S Inhibitors”; Inflammation Research (2001) Sup. 3, vol. 50, p S206, abstr. 079.
Andronati, S.A. et al.: “Synthesis of 1-[4-(4-phenyl-1-piperazinyl)butyl]1,2-dihydro-3H-1,4-benzodiazepin-2-ones and1H-indazoles and their affinity for benzodiazepine receptors”; Chemical Abstracts No. (CAN) 122:314528; (1994) 8:126-131.
Bromme, D, et al.; “High level expression and crystallization of recombinant human cathepsin S”; Protein Science (1996) 5:789-791.
Kirschke, H. et al.; “Cathepsin S”; Handbook of Proteolytic Enzymes; Barrett, A.J.; Rawlings, N.D.; Woessner, J.F., Editors, Academic Press (1998) 621-624.
Nakagawa, T.Y. et al.; “Impaired Invariant Chain Degradation and Antigen Presentation and Diminished Collagen-induced Arthritis in Cathepsin S Null Mice”; Immunity (1999) 10:207-217.
Riese, R.J. et al.; “Cathepsin S Activity Regulates Antigen Presentation and Immunity”; J. Clin. Invest. (1998) 101(11):2351-2363.
Shi, G.P., et al.; “Cathepsin S Required for Normal MHC Class II Peptide Loading and Germinal Center Development”; Immunity (1999) 10:197-206.
Singh, P., et al.; “Quantitative Structure-Activity Relationship Studies on a New Class of Antihypertensive Agents: Derivatives of 3-Aryl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine”; Quant. Struct.-Act. Relat. (1990)9:29-32.
Winters, G. et al.; “Synthesis in Vitro [3H]Prazosin Displacement and in Vivo Activity of 3-Aryl-4,5,6,7-tetrahydropyrazolo(4,3-c)pyridines, a New Class of Antihypertensive”; J. Med. Chem. (1985) 28(7):934-940.
Nakatsuka, Masashi et al.; “Preparation of pyrazole derivatives as immunosuppressants”; retreived from STN Database accession No. 130:52417, XP002193692 abstract; Chemical Abstracts Service, Columbus, Ohio, US.
PCT International Search Report PCT/US01/25180 dated Apr. 5, 2002.
PCT Search Report for PCT/US 01/27441 dated Jul. 18, 2002.
Kaoru Saegusa, et al. “Cathepsin S Inhibitor prevents autoantigen presentation and autoimmunity”, Journal of Clinical Investigation, Aug. 2002, vol. 110, No. 3.
Cai Hui
Edwards James P.
Meduna Steven P.
Pio Barbara A.
Wei Jianmei
Berch Mark L.
Habte Kahsay
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