Substituted pyrazines as inhibitors of platelet aggregation

Details Substituted pyrazines as inhibitors of platelet aggregation Substituted pyrazines as inhibitors of platelet aggregation

1977-05-23

1978-10-31

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

2602855, 424250, 424261, 544336, 544409, C07D24118

Patent

active

041236130

ABSTRACT:
Novel substituted pyrazine derivatives are disclosed having the general formula (I): ##STR1## where R.sub.1 and R.sub.2 may be methyl, methoxy, halogen (particularly chlorine, bromine or fluorine), or hydrogen, with the proviso that R.sub.1 and R.sub.2 cannot both be hydrogen, and X may be S or NH.
These novel substituted pyrazine derivatives show a remarkable activity as inhibitors of platelet aggregation at very low dosages.

REFERENCES:
patent: 3238211 (1966-03-01), Camerino et al.
patent: 3901894 (1975-08-01), Kornfeld et al.
patent: 3996228 (1976-12-01), Arcari et al.
patent: 4004011 (1977-01-01), Hauth et al.

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