Substituted pyranone inhibitors of cholesterol synthesis

Drug – bio-affecting and body treating compositions – Nonspecific immunoeffector – per se ; or nonspecific... – Synthetic or structurally-modified peptidoglycan or...

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542441, 549292, A61K 31365, C07D30930

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active

043754759

ABSTRACT:
6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

REFERENCES:
patent: 3522245 (1970-07-01), Brinkhoff
patent: 3600403 (1971-08-01), Brinkhoff
patent: 3957440 (1976-08-01), Hajos et al.
patent: 3965129 (1976-06-01), Perry et al.
patent: 3983140 (1976-09-01), Endo et al.
patent: 4198425 (1980-04-01), Mitsui et al.
Brown et al., J. Chem. Soc., Perkin I (1976), 1165-1169.
Hulcher, Arch. Biochem & Biophys, 146, 422-427 (1971).
Singer et al., Proc. Soc. Exper. Biol. Med. 102, 370-373 (1959).
Meyer, Liebigs Ann. Chem. (1979) pp. 484-491.

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