Drug – bio-affecting and body treating compositions – Nonspecific immunoeffector – per se ; or nonspecific... – Synthetic or structurally-modified peptidoglycan or...
Patent
1981-02-11
1983-03-01
Demers, Arthur P.
Drug, bio-affecting and body treating compositions
Nonspecific immunoeffector, per se ; or nonspecific...
Synthetic or structurally-modified peptidoglycan or...
542441, 549292, A61K 31365, C07D30930
Patent
active
043754759
ABSTRACT:
6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
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Brown et al., J. Chem. Soc., Perkin I (1976), 1165-1169.
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Cragoe, Jr. Edward J.
Hoffman William F.
Novello Frederick C.
Willard Alvin K.
Demers Arthur P.
Merck & Co. , Inc.
Monaco Mario A.
Nicholson William H.
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