Substituted pyran derivatives having antiinfective activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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549419, A61K 31335, C07D30910

Patent

active

052665933

ABSTRACT:
Novel antibiotic substances, having the general formula ##STR1## wherein A, R.sub.1 and R.sub.2 are as defined herein.

REFERENCES:
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Nakamura et al., C.A., 105:191,400z (1986)-Abstract of EP 188,384.
Miyazaki et al., C.A., 112:317,423f (1990)-Abstract of Chem. Pharm. Bull., 37(9), 2379-90 (1990).
J. P. Van Wauwe et al., "Is There a Case for P-450 Inhibitors in Cancer Treatment?", Journal of Medicinal Chemistry, vol. 32, No. 10 (Oct. 1989), pp. 2231-2239.
R. E. Schwartz et al., "Restricticin, A Novel Glycine-Containing Antifungal Agent", Journal of Antibiotics, vol. 44, No. 5, (May 1991), pp. 463-471.

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