Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent
Reexamination Certificate
2011-05-24
2011-05-24
Wilson, James O (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen in the nitrogen containing substituent
C544S120000, C544S295000
Reexamination Certificate
active
07947830
ABSTRACT:
This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
REFERENCES:
patent: 4455422 (1984-06-01), Banno et al.
patent: 5025012 (1991-06-01), Miura et al.
patent: 7446109 (2008-11-01), Emelen et al.
patent: 7501417 (2009-03-01), Van Emelen et al.
patent: 7541369 (2009-06-01), Angibaud et al.
patent: 7592450 (2009-09-01), Emelen
patent: 7615553 (2009-11-01), Emelen et al.
patent: 7767679 (2010-08-01), Emelen et al.
patent: 2005/0096468 (2005-05-01), Van Emelen et al.
patent: 2005/0107384 (2005-05-01), Angibaud et al.
patent: 2009/0018152 (2009-01-01), Angibaud et al.
patent: 2009/0018153 (2009-01-01), Angibaud et al.
patent: 2009/0036463 (2009-02-01), Angibaud et al.
patent: 2009/0042920 (2009-02-01), Emelen et al.
patent: 2009/0143401 (2009-06-01), Marconnet-Decrane et al.
patent: 2009/0170836 (2009-07-01), Angibaud et al.
patent: 2009/0170881 (2009-07-01), Angibaud et al.
patent: 2009/0221580 (2009-09-01), Angibaud et al.
patent: 2009/0227558 (2009-09-01), Angibaud et al.
patent: 2009/0270419 (2009-10-01), Arts et al.
patent: 2010/0009988 (2010-01-01), Emelen
patent: 2010/0010004 (2010-01-01), Emelen et al.
patent: 2010/0048588 (2010-02-01), Emelen et al.
patent: 2010/0160321 (2010-06-01), Holte et al.
patent: 0 827 742 (1998-03-01), None
patent: 1485365 (2004-12-01), None
patent: 1485378 (2004-12-01), None
patent: 1485348 (2008-06-01), None
patent: 1492534 (2008-06-01), None
patent: 1 485 364 (2009-03-01), None
patent: 1485370 (2009-03-01), None
patent: WO 03/066579 (2003-08-01), None
patent: WO 03/075929 (2003-09-01), None
patent: WO 03075929 (2003-09-01), None
patent: WO 03076400 (2003-09-01), None
patent: WO 03076401 (2003-09-01), None
patent: WO 03076421 (2003-09-01), None
patent: WO 03076422 (2003-09-01), None
patent: WO 03076430 (2003-09-01), None
patent: WO 03076438 (2003-09-01), None
patent: WO 03082288 (2003-10-01), None
patent: WO 03087057 (2003-10-01), None
patent: WO 2004009536 (2004-01-01), None
patent: WO 2004013130 (2004-02-01), None
patent: WO 2004063146 (2004-07-01), None
patent: WO 2004063169 (2004-07-01), None
patent: WO 2004072047 (2004-08-01), None
patent: WO 2004082638 (2004-09-01), None
patent: WO 2004082638 (2004-09-01), None
patent: WO 2004092115 (2004-10-01), None
patent: WO 2005028447 (2005-03-01), None
patent: WO 2005030704 (2005-04-01), None
patent: WO 2005030705 (2005-04-01), None
patent: WO 2005040101 (2005-05-01), None
patent: WO 2005040161 (2005-05-01), None
Dorwald F. A. Side Reactions in Organic Synthesis, 2005, Wiley: VCH, Weinheim p. IX of Preface.
Banker, et. al., Modern Pharmaceuticals, 3rd Ed. p. 596 (1996).
Wolff, Manfred E. Burger's Medicinal Chemistry, 5th Ed. Part 1, pp. 975-977 (1995).
Cecil Textbook of Medicine, 21st Edition (2000), Goldman & Bennett (Editors), W.B. Saunders Company (Publisher), Chapter 198, pp. 1060-1074.
Internal Medicine, 4th Edition, Editor-in-Chief Jay Stein, Chapters 71-72, pp. 699-715.
Finnin et al., “Structures of histone deacetylase homologue bound to the TSA and SAHA inhibitors”, Nature, Sep. 9, 1999, vol. 401, pp. 188-193.
Mosmann Tim, Rapid Colorimetiric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assay', Journal of Immunological Methods, vol. 65, (1983) pp. 55-63.
International Search Report re: PCT/EP2005/053611 date of mailing Jan. 17, 2006.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 12/160,120 dated Sep. 30, 2009, 13 pages.
In the U.S. Patent and Trademark Office, Final Office Action in re: U.S. Appl. No. 12/090,771 dated Aug. 24, 2009, 6 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 12/090,771 dated Dec. 23, 2008, 11 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 12/160,133 dated Sep. 29, 2009, 12 pages.
Gorrod et al., The Metabolism of N-Ethy;-N-methylaniline by Rabbit Liver Microsomes: The Measurement of Metabolites by Gas-Liquid Chromatography. Xenobiotica, 5 (8): 453-463, 1975.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/507,159 dated Jun. 25, 2009, 7 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/507,785 dated May 13, 2008, 6 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/507,785 dated July 19, 2007, 16 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 12/539,682 dated Aug. 17, 2010, 8 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/507,084 dated July 22, 2008, 5 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/507,084 dated Feb. 25, 2008, 5 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/507,084 dated Jun. 1, 2007, 7 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 112/372,801 dated Jun. 10, 2010, 5 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 12/372,801 dated Dec. 10, 2009, 7 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/506,998 dated Oct. 2, 2008, 5 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/506,998 dated Jun. 19, 2007, 7 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 12/233,977 dated Jun. 3, 2010, 6 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/507,788 dated Oct. 19, 2007, 17 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/507,784 dated Feb. 13, 2008, 5 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/507,784 dated Sep. 24, 2007, 5 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/507,784 dated Apr. 6, 2007, 13 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 12/360,139 dated Aug. 19, 2010, 22 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/507,271 dated May 2, 2008, 5 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/507,271 dated Jul. 25, 2007, 12 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 12/160,140 dated Aug. 9, 2010, 6 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 12/160,140 dated Sep. 30, 2009, 14 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 12/160,156 dated Sep. 29, 2009, 13 pages.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 12/160,221 dated Jan. 19, 2010, 7 pages.
Angibaud Patrick Rene
Arts Janine
Marconnet-Decrane Laurence Françoise Bernadette
Van Brandt Sven Franciscus Anna
Van Emelen Kristof
Janssen Pharmaceutica N.V.
Murray Jeffrey H
Patton & Boggs LLP
Wilson James O
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