Substituted prolines as inhibitors of hepatitis C virus NS3...

Details Substituted prolines as inhibitors of hepatitis C virus NS3... Substituted prolines as inhibitors of hepatitis C virus NS3...

2008-07-15

2008-07-15

Gupta, Anish (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S299000, C514S043000, C530S300000, C530S331000

Reexamination Certificate

active

07399749

ABSTRACT:
The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

REFERENCES:
patent: 5712145 (1998-01-01), Houghton et al.
patent: 6608027 (2003-08-01), Tsantrizos et al.
patent: 7012066 (2006-03-01), Saksena et al.
patent: 0 381 216 (1995-12-01), None
patent: WO 89/04669 (1989-06-01), None
patent: WO 98/14181 (1998-04-01), None
patent: WO 98/17679 (1998-04-01), None
patent: WO 98/22496 (1998-05-01), None
patent: WO 99/07734 (1999-02-01), None
patent: WO 00/09543 (2000-02-01), None
patent: WO 00/09558 (2000-02-01), None
patent: WO 00/59929 (2000-10-01), None
patent: WO 01/74768 (2001-10-01), None
patent: WO 01/77113 (2001-10-01), None
patent: WO 01/81325 (2001-11-01), None
patent: WO 02/08187 (2002-01-01), None
patent: WO 02/08198 (2002-01-01), None
patent: WO 02/08244 (2002-01-01), None
patent: WO 02/08251 (2002-01-01), None
patent: WO 02/08256 (2002-01-01), None
patent: WO 02/48172 (2002-06-01), None
Perni, R B et al., “Inhibitors of hepatitis C virus NS3.4A protease 2. Warhead SAR and optimization”, Biorganic & Medicinal Chem Ltrs. (14); pp. 1441-1446 (2004).
International Search Report corresponding to PCT/US2005/017401 dated Oct. 4, 2005.
Berenguer, Marina, et al., “Hepatitis B and C . . . ,” Proceedings of the Association of American Physicians 110(2):98-112 (1998).
Dimasi, Nazzareno, et al., “Characterization of Engineered . . . ,” Journal of Virology 71(10):7461-69 (1997).
Elzouki, Abdul-Nasser, et al., “Serine protease inhibitors . . . ,” Journal of Hepatology 27:42-48 (1997).
Failla, Cristina Maria, et al., “Redesigning the substrate . . . ,” Folding & Design 1(1):35-42 (Jan. 10, 1996).
Han, Wei, et al., “alpha-Ketoamides, alpha-Ketoesters . . . ,” Bioorganic & Medicinal Chemistry Letters 10:711-713 (2000).
Hoofnagle, Jay H., et al., “The Treatment of . . . ,” Drug Therapy 336(5):347-56 (1997).
Ingallinella, Paolo, et al., “Potent Peptide Inhibitors . . . ,” Biochemistry 37:8906-14 (1998).
Kolykhalov, Alexander A., et al., “Specificity of the Hepatitis . . . ,” Journal of Virology 68(11):7525-7533 (Nov. 1994).
Komoda, Yasumasa, et al., “Substrate Requirements of . . . ,” Journal of Virology 68(11):7351-7357 (Nov. 1994).
Landro, James A., et al., “Mechanistic Role of an . . . ,” Biochemistry 36:9340-48 (1997).
Llinas-Brunet, Montse, et al., “Peptide-Based Inhibitors . . . ,” Bioorganic & Medicinal Chemistry Letters 8:1713-1718 (1998).
Marchetti, Antonella, et al., “Synthesis of Two Novel . . . ,” Synlett S1:1000-1002 (1999).
Martin, F., et al., “Affinity selection of a . . . ,” Protein Engineering 10(5):607-14 (1997).
Martin, Franck, et al., “Design of Selective . . . ,” Biochemistry 37:11459-68 (1998).
Pizzi, Elisabetta, et al., “Molecular model of . . . ,” Proc. Natl. Acad. Sci. USA 91:888-892 (Feb. 1994).
BioWorld Tody 9(217):4 (Nov. 10, 1998).
U.S. No. 10/052,386 filed Jan. 18, 2002.

Affiliated with

Also associated with

Rating

Substituted prolines as inhibitors of hepatitis C virus NS3... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted prolines as inhibitors of hepatitis C virus NS3..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted prolines as inhibitors of hepatitis C virus NS3... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2766612