Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-07-14
1986-11-04
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514307, 514333, 514339, 514341, 514397, 514414, 514422, 514423, 540 1, 546147, 546256, 546273, 546276, 546281, 548336, 548356, 548454, 548455, 548456, 548463, 548467, 548468, 548517, 548525, 548527, 548533, 548409, 560 16, 560 34, 562426, 562439, A61K 3144, C07D40112
Patent
active
046210920
ABSTRACT:
Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
REFERENCES:
patent: 4053651 (1977-10-01), Ondetti et al.
patent: 4105776 (1978-08-01), Ondetti et al.
patent: 4129566 (1978-12-01), Ondetti et al.
patent: 4154935 (1979-05-01), Ondetti et al.
patent: 4192878 (1980-03-01), Ondetti
patent: 4199512 (1980-04-01), Ondetti et al.
patent: 4211786 (1980-07-01), Rovnyak
patent: 4217359 (1980-08-01), Krapcho
patent: 4234489 (1980-11-01), Ondetti et al.
patent: 4254267 (1981-03-01), Rovnyak
patent: 4256751 (1981-03-01), Hayashi et al.
patent: 4256761 (1981-03-01), Suh et al.
patent: 4266065 (1981-05-01), Rovnyak
patent: 4296033 (1981-10-01), Petrillo et al.
patent: 4296113 (1981-10-01), Ondetti et al.
patent: 4310461 (1982-01-01), Krapcho
patent: 4311697 (1982-01-01), Krapcho
patent: 4316905 (1982-02-01), Krapcho
patent: 4316906 (1982-02-01), Ondetti et al.
patent: 4329473 (1982-05-01), Almquist et al.
patent: 4337201 (1982-06-01), Petrillo
patent: 4374829 (1983-02-01), Harris et al.
patent: 4470973 (1984-09-01), Natarajan et al.
Almquist et al., "Synthesis and Biological Activity . . . Angiotensin Converting Enzyme", J. Med. Chem., 1980, 23, pp. 1392-1398.
Meyer et al., "Novel Synthesis of (S)--1--[5--(Benzoylamino)--1,4--dioxo--6--phenylhexyl]--L--proline", J. Med. Chem., 1981, 24, pp. 964-969.
Meyer et al., "Angiotensin Converting Enzyme Inhibitors:Modification of a Tripeptide Analogue", J. Med. Chem., 1982, 25, pp. 996-999.
Gordon Eric M.
Natarajan Sesha I.
Davis Stephen B.
E. R. Squibb & Sons Inc.
Levinson Lawrence S.
Raymond Richard L.
Turnipseed James H.
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